Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery
Hypothesis Gemini pyridinium-based amphiphiles can play a triple role as: gold nanoparticles (AuNPs) synthesis facilitator, particle stabilizer and anion recognition centre. The so formed nanoparticles should be able to bind and release anionic drugs. Experiments We describe (a) Synthesis,...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/52919/ |
| _version_ | 1848798840346378240 |
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| author | Alea-Reyes, Maria E. Gonzalez, Asensio Calpena, Ana C. Ramos-López, David Lapuente, Joaquín de Pérez-García, Lluïsa |
| author_facet | Alea-Reyes, Maria E. Gonzalez, Asensio Calpena, Ana C. Ramos-López, David Lapuente, Joaquín de Pérez-García, Lluïsa |
| author_sort | Alea-Reyes, Maria E. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Hypothesis
Gemini pyridinium-based amphiphiles can play a triple role as: gold nanoparticles (AuNPs) synthesis facilitator, particle stabilizer and anion recognition centre. The so formed nanoparticles should be able to bind and release anionic drugs.
Experiments
We describe (a) Synthesis, by a phase transfer method, of both new organic media and water soluble AuNPs using gemini-type surfactants based on bis-pyridinium salts as ligands, acting as transfer agents into organic media and also as nanoparticle stabilizers, (b) Examination of their stability in solution, (c) Chemical and physical characterization of the nanoparticles, (d) Toxicity data concerning both the bis-pyridinium ligands and the bis-pyridinium coated nanoparticles, and (e) Study of their ability for delivering anionic pharmaceuticals such as ibuprofen and piroxicam.
Findings
Pyridinium gemini-type surfactants show the ability to play multiple roles such as transfer agent and stabilizer, as well as ionophores: They are responsible for the preparation, stability, and delivery properties of these AuNPs, which gold core is stabilized by the anions present in the bis-pyridinium salts. The tetrahydropyridine resulting from the reduction of the bis-pyridinium salt is capable of reduce gold, due to its spontaneous oxidation to the corresponding pyridinium salt, leading to the formation of stable AuNPs. |
| first_indexed | 2025-11-14T20:26:10Z |
| format | Article |
| id | nottingham-52919 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:26:10Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-529192020-05-04T19:06:29Z https://eprints.nottingham.ac.uk/52919/ Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery Alea-Reyes, Maria E. Gonzalez, Asensio Calpena, Ana C. Ramos-López, David Lapuente, Joaquín de Pérez-García, Lluïsa Hypothesis Gemini pyridinium-based amphiphiles can play a triple role as: gold nanoparticles (AuNPs) synthesis facilitator, particle stabilizer and anion recognition centre. The so formed nanoparticles should be able to bind and release anionic drugs. Experiments We describe (a) Synthesis, by a phase transfer method, of both new organic media and water soluble AuNPs using gemini-type surfactants based on bis-pyridinium salts as ligands, acting as transfer agents into organic media and also as nanoparticle stabilizers, (b) Examination of their stability in solution, (c) Chemical and physical characterization of the nanoparticles, (d) Toxicity data concerning both the bis-pyridinium ligands and the bis-pyridinium coated nanoparticles, and (e) Study of their ability for delivering anionic pharmaceuticals such as ibuprofen and piroxicam. Findings Pyridinium gemini-type surfactants show the ability to play multiple roles such as transfer agent and stabilizer, as well as ionophores: They are responsible for the preparation, stability, and delivery properties of these AuNPs, which gold core is stabilized by the anions present in the bis-pyridinium salts. The tetrahydropyridine resulting from the reduction of the bis-pyridinium salt is capable of reduce gold, due to its spontaneous oxidation to the corresponding pyridinium salt, leading to the formation of stable AuNPs. Elsevier 2017-09-15 Article PeerReviewed Alea-Reyes, Maria E., Gonzalez, Asensio, Calpena, Ana C., Ramos-López, David, Lapuente, Joaquín de and Pérez-García, Lluïsa (2017) Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery. Journal of Colloid and Interface Science, 502 . pp. 172-183. ISSN 1095-7103 Gemini pyridinium amphiphiles; Tetrahydropyridines; Gold nanoparticles; Anionic drug encapsulation https://www.sciencedirect.com/science/article/pii/S0021979717304642?via%3Dihub doi:10.1016/j.jcis.2017.04.064 doi:10.1016/j.jcis.2017.04.064 |
| spellingShingle | Gemini pyridinium amphiphiles; Tetrahydropyridines; Gold nanoparticles; Anionic drug encapsulation Alea-Reyes, Maria E. Gonzalez, Asensio Calpena, Ana C. Ramos-López, David Lapuente, Joaquín de Pérez-García, Lluïsa Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title | Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title_full | Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title_fullStr | Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title_full_unstemmed | Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title_short | Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| title_sort | gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery |
| topic | Gemini pyridinium amphiphiles; Tetrahydropyridines; Gold nanoparticles; Anionic drug encapsulation |
| url | https://eprints.nottingham.ac.uk/52919/ https://eprints.nottingham.ac.uk/52919/ https://eprints.nottingham.ac.uk/52919/ |