PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy

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PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy

The lung remains an attractive target for the gene therapy of monogenetic diseases such as cystic fibrosis (CF). Despite over 27 clinical trials, there are still very few gene therapy vectors that have shown any improvement in lung function; highlighting the need to develop formulations with improve...

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Bibliographic Details
Main Authors:	Osman, Gizem, Rodriguez, Jason, Chan, Sze Yan, Chisholm, Jane, Duncan, Gregg, Kim, Namho, Tatler, Amanda L., Shakesheff, Kevin M., Hanes, Justin, Suk, Jung Soo, Dixon, James E.
Format:	Article
Published:	Elsevier 2018
Subjects:	Glycosaminoglycan-binding enhanced transduction (GET); Lung; Transfection; Gene therapy; Cell-penetrating peptide (CPP); Plasmid DNA (pDNA)
Online Access:	https://eprints.nottingham.ac.uk/52893/

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