Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?

Potentiation of latent inhibition by haloperidol and clozapine is attenuated in Dopamine D2 receptor (Drd-2) deficient mice: Do antipsychotics influence learning to ignore irrelevant stimuli via both Drd-2 and non-Drd-2 mechanisms?

Whether the dopamine Drd-2 receptor is necessary for the behavioural action of antipsychotic drugs is an important question, as Drd-2 antagonism is responsible for their debilitating motor side effects. Using Drd-2 null mice (Drd2 -/-) it has previously been shown that Drd-2 is not necessary for ant...

Full description

Bibliographic Details
Main Authors: O'Callaghan, M.J., Bay-Richter, C., O’ Tuathaigh, Colm M.P., Heery, David M., Waddington, J.L., Moran, Paula M.
Format: Article
Published: Sage 2014
Subjects:
Antipsychotics; Drd-2 knockout mice; Latent inhibition; Haloperidol; Clozapine
Online Access:https://eprints.nottingham.ac.uk/52889/

Similar Items

Similar Items