Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis
In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS in preclinical and clinical studies. It was hypoth...
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| Format: | Article |
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Lippincott, Williams & Wilkins
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52835/ |
| _version_ | 1848798821449990144 |
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| author | Hunt, James Russell Goff, Megan Jenkins, Helen Harris, John Knowles, Toby G. Lascelles, Duncan Enomoto, Masataka Mendl, Mike Whay, Becky Murrell, Jo C. |
| author_facet | Hunt, James Russell Goff, Megan Jenkins, Helen Harris, John Knowles, Toby G. Lascelles, Duncan Enomoto, Masataka Mendl, Mike Whay, Becky Murrell, Jo C. |
| author_sort | Hunt, James Russell |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS in preclinical and clinical studies. It was hypothesised that dogs suffering from OA would exhibit electrophysiological characteristics indicative of CS, associated with reduced diffuse noxious inhibitory controls (DNIC). 117 client owned dogs were recruited to the study. Hindlimb nociceptive withdrawal reflex (NWR) thresholds, stimulus response, and temporal summation characteristics were recorded, during alfaxalone anaesthesia, from 46 OA dogs, 29 OA dogs receiving non-steroidal anti-inflammatory drugs (OANSAID), and 27 breed- and weight-matched control dogs. Efficacy of DNIC was evaluated in 12 control and 11 of the OA dogs, by application of a mechanical conditioning stimulus to the contralateral forelimb. NWR thresholds were higher in OA compared with control dogs (p = 0.02). Stimulus response characteristics demonstrated an augmented response in OANSAID dogs compared with OA (p < 0.001) and control (p < 0.001) dogs. Temporal summation demonstrated exaggerated C-fibre mediated responses in both OA (p < 0.001) and OANSAID (p = 0.005) groups, compared with control animals. Conditioning stimulus application resulted in inhibition of test reflex responses in both OA and control animals (p < 0.001); control animals demonstrated greater inhibition compared with OA (p = 0.0499). These data provide evidence of neurophysiological changes consistent with CS in dogs with spontaneous OA, and demonstrate that canine OA is associated with reduced DNIC. |
| first_indexed | 2025-11-14T20:25:52Z |
| format | Article |
| id | nottingham-52835 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:25:52Z |
| publishDate | 2018 |
| publisher | Lippincott, Williams & Wilkins |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-528352020-05-04T19:45:35Z https://eprints.nottingham.ac.uk/52835/ Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis Hunt, James Russell Goff, Megan Jenkins, Helen Harris, John Knowles, Toby G. Lascelles, Duncan Enomoto, Masataka Mendl, Mike Whay, Becky Murrell, Jo C. In man, central sensitisation (CS) contributes to the pain of osteoarthritis (OA). Dogs with spontaneous OA may also exhibit CS. Electrophysiological reflex measurements are more objective than behavioural assessments, and can be used to evaluate CS in preclinical and clinical studies. It was hypothesised that dogs suffering from OA would exhibit electrophysiological characteristics indicative of CS, associated with reduced diffuse noxious inhibitory controls (DNIC). 117 client owned dogs were recruited to the study. Hindlimb nociceptive withdrawal reflex (NWR) thresholds, stimulus response, and temporal summation characteristics were recorded, during alfaxalone anaesthesia, from 46 OA dogs, 29 OA dogs receiving non-steroidal anti-inflammatory drugs (OANSAID), and 27 breed- and weight-matched control dogs. Efficacy of DNIC was evaluated in 12 control and 11 of the OA dogs, by application of a mechanical conditioning stimulus to the contralateral forelimb. NWR thresholds were higher in OA compared with control dogs (p = 0.02). Stimulus response characteristics demonstrated an augmented response in OANSAID dogs compared with OA (p < 0.001) and control (p < 0.001) dogs. Temporal summation demonstrated exaggerated C-fibre mediated responses in both OA (p < 0.001) and OANSAID (p = 0.005) groups, compared with control animals. Conditioning stimulus application resulted in inhibition of test reflex responses in both OA and control animals (p < 0.001); control animals demonstrated greater inhibition compared with OA (p = 0.0499). These data provide evidence of neurophysiological changes consistent with CS in dogs with spontaneous OA, and demonstrate that canine OA is associated with reduced DNIC. Lippincott, Williams & Wilkins 2018-07-09 Article PeerReviewed Hunt, James Russell, Goff, Megan, Jenkins, Helen, Harris, John, Knowles, Toby G., Lascelles, Duncan, Enomoto, Masataka, Mendl, Mike, Whay, Becky and Murrell, Jo C. (2018) Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis. Pain . ISSN 1872-6623 Central sensitisation; Diffuse Noxious Inhibitory Controls; Dog; Nociceptive Withdrawal Reflex; Osteoarthritis https://journals.lww.com/pain/Abstract/publishahead/Electrophysiological_Characterisation_of_Central.98906.aspx doi:10.1097/j.pain.0000000000001336 doi:10.1097/j.pain.0000000000001336 |
| spellingShingle | Central sensitisation; Diffuse Noxious Inhibitory Controls; Dog; Nociceptive Withdrawal Reflex; Osteoarthritis Hunt, James Russell Goff, Megan Jenkins, Helen Harris, John Knowles, Toby G. Lascelles, Duncan Enomoto, Masataka Mendl, Mike Whay, Becky Murrell, Jo C. Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title | Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title_full | Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title_fullStr | Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title_full_unstemmed | Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title_short | Electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| title_sort | electrophysiological characterisation of central sensitisation in canine spontaneous osteoarthritis |
| topic | Central sensitisation; Diffuse Noxious Inhibitory Controls; Dog; Nociceptive Withdrawal Reflex; Osteoarthritis |
| url | https://eprints.nottingham.ac.uk/52835/ https://eprints.nottingham.ac.uk/52835/ https://eprints.nottingham.ac.uk/52835/ |