Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity
Two new Cu(II) complexes [Cu(L1)(N3)](1) and [Cu(L1)(NCS)]n(2), where HL1 ((E)-4-((2(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol) is a N,N,O-donor Schiff base ligand, have been synthesized. These complexes were characterized on the basis of spectroscopic, electrochemical,...
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| Format: | Article |
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Royal Society of Chemistry
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52789/ |
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| author | Mondal, Satyajit Chakraborty, Moumita Mondal, Antu Pakhira, Bholanath Blake, Alexander J. Sinn, Ekkehard Chattopadhyay, Shyamal Kumar |
| author_facet | Mondal, Satyajit Chakraborty, Moumita Mondal, Antu Pakhira, Bholanath Blake, Alexander J. Sinn, Ekkehard Chattopadhyay, Shyamal Kumar |
| author_sort | Mondal, Satyajit |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Two new Cu(II) complexes [Cu(L1)(N3)](1) and [Cu(L1)(NCS)]n(2), where HL1 ((E)-4-((2(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol) is a N,N,O-donor Schiff base ligand, have been synthesized. These complexes were characterized on the basis of spectroscopic, electrochemical, and other physicochemical properties. X-ray crystal structure determination reveals that in complex 1, Cu(II) is in a square planar geometry with the N,N,O-donor ligand and a terminally coordinated azide ion. In complex 2, however, Cu(II) assumes a square pyramidal geometry, and apart from the tridentate Schiff base ligand there is a thiocyanate ion, which acts in a μ1,3-bridging mode, connecting adjacent Cu(II) atoms in an axial-equatorial fashion forming an one dimensional chain. Cyclic voltammetry shows that complexes undergo Cu(II)/Cu(I) reductions at −0.40 to −0.55V followed by imine reduction at around −0.7V. Cu(I)/Cu(0) reduction is observed at approximately −0.9V. Complex 1 also shows appreciable catalytic activity for the aerial oxidation of 3,5 DTBCH2 to DTBQ (catecholase activity). Both the complexes also show strong binding affinity towards calf-thymus DNA. |
| first_indexed | 2025-11-14T20:25:41Z |
| format | Article |
| id | nottingham-52789 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:25:41Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-527892020-05-04T19:41:44Z https://eprints.nottingham.ac.uk/52789/ Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity Mondal, Satyajit Chakraborty, Moumita Mondal, Antu Pakhira, Bholanath Blake, Alexander J. Sinn, Ekkehard Chattopadhyay, Shyamal Kumar Two new Cu(II) complexes [Cu(L1)(N3)](1) and [Cu(L1)(NCS)]n(2), where HL1 ((E)-4-((2(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol) is a N,N,O-donor Schiff base ligand, have been synthesized. These complexes were characterized on the basis of spectroscopic, electrochemical, and other physicochemical properties. X-ray crystal structure determination reveals that in complex 1, Cu(II) is in a square planar geometry with the N,N,O-donor ligand and a terminally coordinated azide ion. In complex 2, however, Cu(II) assumes a square pyramidal geometry, and apart from the tridentate Schiff base ligand there is a thiocyanate ion, which acts in a μ1,3-bridging mode, connecting adjacent Cu(II) atoms in an axial-equatorial fashion forming an one dimensional chain. Cyclic voltammetry shows that complexes undergo Cu(II)/Cu(I) reductions at −0.40 to −0.55V followed by imine reduction at around −0.7V. Cu(I)/Cu(0) reduction is observed at approximately −0.9V. Complex 1 also shows appreciable catalytic activity for the aerial oxidation of 3,5 DTBCH2 to DTBQ (catecholase activity). Both the complexes also show strong binding affinity towards calf-thymus DNA. Royal Society of Chemistry 2018-06-21 Article PeerReviewed Mondal, Satyajit, Chakraborty, Moumita, Mondal, Antu, Pakhira, Bholanath, Blake, Alexander J., Sinn, Ekkehard and Chattopadhyay, Shyamal Kumar (2018) Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity. New Journal of Chemistry, 42 (12). pp. 9588-9597. ISSN 1369-9261 http://pubs.rsc.org/en/Content/ArticleLanding/2018/NJ/C8NJ00418H#!divAbstract doi:10.1039/C8NJ00418H doi:10.1039/C8NJ00418H |
| spellingShingle | Mondal, Satyajit Chakraborty, Moumita Mondal, Antu Pakhira, Bholanath Blake, Alexander J. Sinn, Ekkehard Chattopadhyay, Shyamal Kumar Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title | Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title_full | Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title_fullStr | Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title_full_unstemmed | Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title_short | Cu(ii) complexes of a tridentate N,N,O-donor Schiff base of pyridoxal: synthesis, X-ray structures, DNA-binding properties and catecholase activity |
| title_sort | cu(ii) complexes of a tridentate n,n,o-donor schiff base of pyridoxal: synthesis, x-ray structures, dna-binding properties and catecholase activity |
| url | https://eprints.nottingham.ac.uk/52789/ https://eprints.nottingham.ac.uk/52789/ https://eprints.nottingham.ac.uk/52789/ |