Analysis of shared heritability in common disorders of the brain
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap.We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and a...
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| Format: | Article |
| Published: |
American Association for the Advancement of Science
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52705/ |
| _version_ | 1848798790546358272 |
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| author | Anttila, Verneri Bulik-Sullivan, Brendan Finucane, Hilary K. Walters, Raymond K. Bras, Jose Duncan, Laramie Escott-Price, Valentina Falcone, Guido J. Gormley, Padhraig Malik, Rainer Patsopoulos, Nikolaos A. Ripke, Stephan Wei, Zhi Yu, Dongmei Lee, Phil H. Turley, Patrick Grenier-Boley, Benjamin Chouraki, Vincent Kamatani, Yoichiro Berr, Claudine Letenneur, Luc Hannequin, Didier Amouyel, Philippe Boland, Anne Deleuze, Jean-François Duron, Emmanuelle Vardarajan, Badri N. Reitz, Christiane Goate, Alison M. Huentelman, Matthew J. Kamboh, M. Ilyas Larson, Eric B. Rogaeva, Ekaterina St George-Hyslop, Peter Hakonarson, Hakon Kukull, Walter A. Farrer, Lindsay A. Barnes, Lisa L. Beach, Thomas G. Demirci, F. Yesim Head, Elizabeth Hulette, Christine M. Jicha, Gregory A. Kauwe, John S.K. Kaye, Jeffrey A. Leverenz, James B. Levey, Allan I. Lieberman, Andrew P. Pankratz, Vernon S. Poon, Wayne W. Quinn, Joseph F. Saykin, Andrew J. Schneider, Lon S. Smith, Amanda G. Sonnen, Joshua A. Stern, Robert A. Van Deerlin, Vivianna M. Van Eldik, Linda J. Harold, Denise Russo, Giancarlo Rubinsztein, David C. Bayer, Anthony Tsolaki, Magda Proitsi, Petra Fox, Nick C. Hampel, Harald Owen, Michael J. Mead, Simon Passmore, Peter Morgan, Kevin Nöthen, Markus M. Rossor, Martin Lupton, Michelle K. Hoffmann, Per Kornhuber, Johannes Lawlor, Brian McQuillin, Andrew Al-Chalabi, Ammar Bis, Joshua C Ruiz, Agustin Boada, Mercè Seshadri, Sudha Beiser, Alexa Rice, Kenneth van der Lee, Sven J. De Jager, Philip L. Geschwind, Daniel H. Riemenschneider, Matthias Riedel-Heller, Steffi Rotter, Jerome I Ransmayr, Gerhard Hyman, Bradley T. Cruchaga, Carlos Alegret, Montserrat Winsvold, Bendik Palta, Priit Farh, Kai-How Cuenca-Leon, Ester Furlotte, Nicholas Kurth, Tobias Ligthart, Lannie Terwindt, Gisela M. Freilinger, Tobias Ran, Caroline Gordon, Scott D. Borck, Guntram Adams, Hieab H.H. Lehtimäki, Terho Wedenoja, Juho Buring, Julie E. Schürks, Markus Hrafnsdottir, Maria Hottenga, Jouke-Jan Penninx, Brenda Artto, Ville Kaunisto, Mari Vepsäläinen, Salli Martin, Nicholas G. Montgomery, Grant W. Kurki, Mitja I. Hämäläinen, Eija Huang, Hailiang Huang, Jie Sandor, Cynthia Webber, Caleb Muller-Myhsok, Bertram Schreiber, Stefan Salomaa, Veikko Loehrer, Elizabeth Göbel, Hartmut Macaya, Alfons Pozo-Rosich, Patricia Hansen, Thomas Werge, Thomas Kaprio, Jaakko Metspalu, Andres Kubisch, Christian Ferrari, Michel D. Belin, Andrea C. van den Maagdenberg, Arn M.J.M. Zwart, John-Anker Boomsma, Dorret Eriksson, Nicholas Olesen, Jes Chasman, Daniel I. Nyholt, Dale R. Avbersek, Andreja Baum, Larry Berkovic, Samuel Bradfield, Jonathan Buono, Russell Catarino, Claudia B. Cossette, Patrick De Jonghe, Peter Depondt, Chantal Dlugos, Dennis Ferraro, Thomas N. French, Jacqueline Hjalgrim, Helle Jamnadas-Khoda, Jennifer Kälviäinen, Reetta Kunz, Wolfram S. Lerche, Holger Leu, Costin Lindhout, Dick Lo, Warren Lowenstein, Daniel McCormack, Mark Møller, Rikke S. Molloy, Anne Ng, Ping-Wing Oliver, Karen Privitera, Michael Radtke, Rodney Ruppert, Ann-Kathrin Sander, Thomas Schachter, Steven Schankin, Christoph Scheffer, Ingrid Schoch, Susanne Sisodiya, Sanjay M. Smith, Philip Sperling, Michael Striano, Pasquale Surges, Rainer Thomas, G. Neil Visscher, Frank Whelan, Christopher D. Zara, Federico Heinzen, Erin L. Marson, Anthony Becker, Felicitas Stroink, Hans Zimprich, Fritz Gasser, Thomas Gibbs, Raphael Heutink, Peter Martinez, Maria Morris, Huw R. Sharma, Manu Ryten, Mina Mok, Kin Y. Pulit, Sara Bevan, Steve Holliday, Elizabeth Attia, John Battey, Thomas Boncoraglio, Giorgio Thijs, Vincent Chen, Wei-Min Mitchell, Braxton Rothwell, Peter Sharma, Pankaj Sudlow, Cathie Vicente, Astrid Markus, Hugh Kourkoulis, Christina Pera, Joana Raffeld, Miriam Silliman, Scott Boraska Perica, Vesna Thornton, Laura M. Huckins, Laura M. William Rayner, N. Lewis, Cathryn M. Gratacos, Monica Rybakowski, Filip Keski-Rahkonen, Anna Raevuori, Anu Hudson, James I. Reichborn-Kjennerud, Ted Monteleone, Palmiero Karwautz, Andreas Mannik, Katrin Baker, Jessica H. O’Toole, Julie K. Trace, Sara E. Davis, Oliver S. P. Helder, Sietske G. Ehrlich, Stefan Herpertz-Dahlmann, Beate Danner, Unna N. van Elburg, Annemarie A. Clementi, Maurizio Forzan, Monica Docampo, Elisa Lissowska, Jolanta Hauser, Joanna Tortorella, Alfonso Maj, Mario Gonidakis, Fragiskos Tziouvas, Konstantinos Papezova, Hana Yilmaz, Zeynep Wagner, Gudrun Cohen-Woods, Sarah Herms, Stefan Julià, Antonio Rabionet, Raquel Dick, Danielle M. Ripatti, Samuli Andreassen, Ole A. Espeseth, Thomas Lundervold, Astri J. Steen, Vidar M. Pinto, Dalila Scherer, Stephen W. Aschauer, Harald Schosser, Alexandra Alfredsson, Lars Padyukov, Leonid Halmi, Katherine A. Mitchell, James Strober, Michael Bergen, Andrew W. Kaye, Walter Szatkiewicz, Jin Peng Cormand, Bru Ramos-Quiroga, Josep Antoni Sánchez-Mora, Cristina Ribasés, Marta Casas, Miguel Hervas, Amaia Arranz, Maria Jesús Haavik, Jan Zayats, Tetyana Johansson, Stefan Williams, Nigel Dempfle, Astrid Rothenberger, Aribert Kuntsi, Jonna Oades, Robert D. Banaschewski, Tobias Franke, Barbara Buitelaar, Jan K. Arias Vasquez, Alejandro Doyle, Alysa E. Reif, Andreas Lesch, Klaus-Peter Freitag, Christine Rivero, Olga Palmason, Haukur Romanos, Marcel Langley, Kate Rietschel, Marcella Witt, Stephanie H. Dalsgaard, Soeren Børglum, Anders D. Waldman, Irwin Wilmot, Beth Molly, Nikolas Bau, Claiton H.D. Crosbie, Jennifer Schachar, Russell Loo, Sandra K. McGough, James J. Grevet, Eugenio H. Medland, Sarah E. Robinson, Elise Weiss, Lauren A. Bacchelli, Elena Bailey, Anthony Bal, Vanessa Battaglia, Agatino Betancur, Catalina Bolton, Patrick Cantor, Rita Celestino-Soper, Patrícia Dawson, Geraldine De Rubeis, Silvia Duque, Frederico Green, Andrew Klauck, Sabine M. Leboyer, Marion Levitt, Pat Maestrini, Elena Mane, Shrikant De-Luca, Daniel Moreno- Parr, Jeremy Regan, Regina Reichenberg, Abraham Sandin, Sven Vorstman, Jacob Wassink, Thomas Wijsman, Ellen Cook, Edwin Santangelo, Susan Delorme, Richard Rogé, Bernadette Magalhaes, Tiago Arking, Dan Schulze, Thomas G. Thompson, Robert C. Strohmaier, Jana Matthews, Keith Melle, Ingrid Morris, Derek Blackwood, Douglas McIntosh, Andrew Bergen, Sarah E Schalling, Martin Jamain, Stéphane Maaser, Anna Fischer, Sascha B. Reinbold, Céline S. Fullerton, Janice M. Guzman-Parra, José Mayoral, Fermin Schofield, Peter R. Cichon, Sven Mühleisen, Thomas W. Degenhardt, Franziska Schumacher, Johannes Bauer, Michael Mitchell, Philip B. Gershon, Elliot S. Rice, John Potash, James B. Zandi, Peter P. Craddock, Nick Ferrier, I. Nicol Alda, Martin Rouleau, Guy A. Turecki, Gustavo Ophoff, Roel Pato, Carlos Anjorin, Adebayo Stahl, Eli Leber, Markus Czerski, Piotr M. Cruceanu, Cristiana Jones, Ian R. Posthuma, Danielle Andlauer, Till F.M. Forstner, Andreas J. Streit, Fabian Baune, Bernhard T. Air, Tracy Sinnamon, Grant Wray, Naomi R. MacIntyre, Donald J. Porteous, David Homuth, Georg Rivera, Margarita Grove, Jakob Middeldorp, Christel M. Hickie, Ian Pergadia, Michele Mehta, Divya Smit, Johannes H. Jansen, Rick de Geus, Eco Dunn, Erin Li, Qingqin S. Nauck, Matthias Schoevers, Robert A. Beekman, Aartjan TF Knowles, James A. Viktorin, Alexander Arnold, Paul Barr, Cathy L. Bedoya-Berrio, Gabriel Bienvenu, O. Joseph Brentani, Helena Burton, Christie Camarena, Beatriz Cappi, Carolina Cath, Danielle Cavallini, Maria Cusi, Daniele Darrow, Sabrina Denys, Damiaan Derks, Eske M. Dietrich, Andrea Fernandez, Thomas Figee, Martijn Freimer, Nelson Gerber, Gloria Grados, Marco Greenberg, Erica Hanna, Gregory L. Hartmann, Andreas Hirschtritt, Matthew E. Hoekstra, Pieter J. Huang, Alden Huyser, Chaim Illmann, Cornelia Jenike, Michael Kuperman, Samuel Leventhal, Bennett Lochner, Christine Lyon, Gholson J. Macciardi, Fabio Madruga-Garrido, Marcos Malaty, Irene A. Maras, Athanasios McGrath, Lauren Miguel, Eurípedes C. Mir, Pablo Nestadt, Gerald Nicolini, Humberto Okun, Michael S. Pakstis, Andrew Paschou, Peristera Piacentini, John Pittenger, Christopher Plessen, Kerstin Ramensky, Vasily Ramos, Eliana M. Reus, Victor Richter, Margaret A. Riddle, Mark A. Robertson, Mary M. Roessner, Veit Rosário, Maria Samuels, Jack F. Sandor, Paul Stein, Dan J. Tsetsos, Fotis Van Nieuwerburgh, Filip Weatherall, Sarah Wendland, Jens R. Wolanczyk, Tomasz Worbe, Yulia Zai, Gwyneth Goes, Fernando S. McLaughlin, Nicole Nestadt, Paul S. Grabe, Hans-Jorgen Depienne, Christel Konkashbaev, Anuar Lanzagorta, Nuria Valencia-Duarte, Ana Bramon, Elvira Buccola, Nancy Cahn, Wiepke Cairns, Murray Chong, Siow A. Cohen, David Crespo-Facorro, Benedicto Crowley, James Davidson, Michael DeLisi, Lynn Dinan, Timothy Donohoe, Gary Drapeau, Elodie Duan, Jubao Haan, Lieuwe Hougaard, David Karachanak-Yankova, Sena Khrunin, Andrey Klovins, Janis Kučinskas, Vaidutis Lee Chee Keong, Jimmy Limborska, Svetlana Loughland, Carmel Lönnqvist, Jouko Maher, Brion Mattheisen, Manuel McDonald, Colm Murphy, Kieran C. Nenadic, Igor van Os, Jim Pantelis, Christos Pato, Michele Petryshen, Tracey Quested, Digby Roussos, Panos Sanders, Alan R. Schall, Ulrich Schwab, Sibylle G. Sim, Kang So, Hon-Cheong Stögmann, Elisabeth Subramaniam, Mythily Toncheva, Draga Waddington, John Walters, James Weiser, Mark Cheng, Wei Cloninger, Robert Curtis, David Gejman, Pablo V. Henskens, Frans Mattingsdal, Morten Oh, Sang-Yun Scott, Rodney Webb, Bradley Breen, Gerome Churchhouse, Claire Bulik, Cynthia M. Daly, Mark Dichgans, Martin Faraone, Stephen V. Guerreiro, Rita Holmans, Peter Kendler, Kenneth S. Koeleman, Bobby Mathews, Carol A. Price, Alkes Scharf, Jeremiah Sklar, Pamela Williams, Julie Wood, Nicholas W. Cotsapas, Chris Palotie, Aarno Smoller, Jordan W. Sullivan, Patrick Rosand, Jonathan Corvin, Aiden Neale, Benjamin M. |
| author_facet | Anttila, Verneri Bulik-Sullivan, Brendan Finucane, Hilary K. Walters, Raymond K. Bras, Jose Duncan, Laramie Escott-Price, Valentina Falcone, Guido J. Gormley, Padhraig Malik, Rainer Patsopoulos, Nikolaos A. Ripke, Stephan Wei, Zhi Yu, Dongmei Lee, Phil H. Turley, Patrick Grenier-Boley, Benjamin Chouraki, Vincent Kamatani, Yoichiro Berr, Claudine Letenneur, Luc Hannequin, Didier Amouyel, Philippe Boland, Anne Deleuze, Jean-François Duron, Emmanuelle Vardarajan, Badri N. Reitz, Christiane Goate, Alison M. Huentelman, Matthew J. Kamboh, M. Ilyas Larson, Eric B. Rogaeva, Ekaterina St George-Hyslop, Peter Hakonarson, Hakon Kukull, Walter A. Farrer, Lindsay A. Barnes, Lisa L. Beach, Thomas G. Demirci, F. Yesim Head, Elizabeth Hulette, Christine M. Jicha, Gregory A. Kauwe, John S.K. Kaye, Jeffrey A. Leverenz, James B. Levey, Allan I. Lieberman, Andrew P. Pankratz, Vernon S. Poon, Wayne W. Quinn, Joseph F. Saykin, Andrew J. Schneider, Lon S. Smith, Amanda G. Sonnen, Joshua A. Stern, Robert A. Van Deerlin, Vivianna M. Van Eldik, Linda J. Harold, Denise Russo, Giancarlo Rubinsztein, David C. Bayer, Anthony Tsolaki, Magda Proitsi, Petra Fox, Nick C. Hampel, Harald Owen, Michael J. Mead, Simon Passmore, Peter Morgan, Kevin Nöthen, Markus M. Rossor, Martin Lupton, Michelle K. Hoffmann, Per Kornhuber, Johannes Lawlor, Brian McQuillin, Andrew Al-Chalabi, Ammar Bis, Joshua C Ruiz, Agustin Boada, Mercè Seshadri, Sudha Beiser, Alexa Rice, Kenneth van der Lee, Sven J. De Jager, Philip L. Geschwind, Daniel H. Riemenschneider, Matthias Riedel-Heller, Steffi Rotter, Jerome I Ransmayr, Gerhard Hyman, Bradley T. Cruchaga, Carlos Alegret, Montserrat Winsvold, Bendik Palta, Priit Farh, Kai-How Cuenca-Leon, Ester Furlotte, Nicholas Kurth, Tobias Ligthart, Lannie Terwindt, Gisela M. Freilinger, Tobias Ran, Caroline Gordon, Scott D. Borck, Guntram Adams, Hieab H.H. Lehtimäki, Terho Wedenoja, Juho Buring, Julie E. Schürks, Markus Hrafnsdottir, Maria Hottenga, Jouke-Jan Penninx, Brenda Artto, Ville Kaunisto, Mari Vepsäläinen, Salli Martin, Nicholas G. Montgomery, Grant W. Kurki, Mitja I. Hämäläinen, Eija Huang, Hailiang Huang, Jie Sandor, Cynthia Webber, Caleb Muller-Myhsok, Bertram Schreiber, Stefan Salomaa, Veikko Loehrer, Elizabeth Göbel, Hartmut Macaya, Alfons Pozo-Rosich, Patricia Hansen, Thomas Werge, Thomas Kaprio, Jaakko Metspalu, Andres Kubisch, Christian Ferrari, Michel D. Belin, Andrea C. van den Maagdenberg, Arn M.J.M. Zwart, John-Anker Boomsma, Dorret Eriksson, Nicholas Olesen, Jes Chasman, Daniel I. Nyholt, Dale R. Avbersek, Andreja Baum, Larry Berkovic, Samuel Bradfield, Jonathan Buono, Russell Catarino, Claudia B. Cossette, Patrick De Jonghe, Peter Depondt, Chantal Dlugos, Dennis Ferraro, Thomas N. French, Jacqueline Hjalgrim, Helle Jamnadas-Khoda, Jennifer Kälviäinen, Reetta Kunz, Wolfram S. Lerche, Holger Leu, Costin Lindhout, Dick Lo, Warren Lowenstein, Daniel McCormack, Mark Møller, Rikke S. Molloy, Anne Ng, Ping-Wing Oliver, Karen Privitera, Michael Radtke, Rodney Ruppert, Ann-Kathrin Sander, Thomas Schachter, Steven Schankin, Christoph Scheffer, Ingrid Schoch, Susanne Sisodiya, Sanjay M. Smith, Philip Sperling, Michael Striano, Pasquale Surges, Rainer Thomas, G. Neil Visscher, Frank Whelan, Christopher D. Zara, Federico Heinzen, Erin L. Marson, Anthony Becker, Felicitas Stroink, Hans Zimprich, Fritz Gasser, Thomas Gibbs, Raphael Heutink, Peter Martinez, Maria Morris, Huw R. Sharma, Manu Ryten, Mina Mok, Kin Y. Pulit, Sara Bevan, Steve Holliday, Elizabeth Attia, John Battey, Thomas Boncoraglio, Giorgio Thijs, Vincent Chen, Wei-Min Mitchell, Braxton Rothwell, Peter Sharma, Pankaj Sudlow, Cathie Vicente, Astrid Markus, Hugh Kourkoulis, Christina Pera, Joana Raffeld, Miriam Silliman, Scott Boraska Perica, Vesna Thornton, Laura M. Huckins, Laura M. William Rayner, N. Lewis, Cathryn M. Gratacos, Monica Rybakowski, Filip Keski-Rahkonen, Anna Raevuori, Anu Hudson, James I. Reichborn-Kjennerud, Ted Monteleone, Palmiero Karwautz, Andreas Mannik, Katrin Baker, Jessica H. O’Toole, Julie K. Trace, Sara E. Davis, Oliver S. P. Helder, Sietske G. Ehrlich, Stefan Herpertz-Dahlmann, Beate Danner, Unna N. van Elburg, Annemarie A. Clementi, Maurizio Forzan, Monica Docampo, Elisa Lissowska, Jolanta Hauser, Joanna Tortorella, Alfonso Maj, Mario Gonidakis, Fragiskos Tziouvas, Konstantinos Papezova, Hana Yilmaz, Zeynep Wagner, Gudrun Cohen-Woods, Sarah Herms, Stefan Julià, Antonio Rabionet, Raquel Dick, Danielle M. Ripatti, Samuli Andreassen, Ole A. Espeseth, Thomas Lundervold, Astri J. Steen, Vidar M. Pinto, Dalila Scherer, Stephen W. Aschauer, Harald Schosser, Alexandra Alfredsson, Lars Padyukov, Leonid Halmi, Katherine A. Mitchell, James Strober, Michael Bergen, Andrew W. Kaye, Walter Szatkiewicz, Jin Peng Cormand, Bru Ramos-Quiroga, Josep Antoni Sánchez-Mora, Cristina Ribasés, Marta Casas, Miguel Hervas, Amaia Arranz, Maria Jesús Haavik, Jan Zayats, Tetyana Johansson, Stefan Williams, Nigel Dempfle, Astrid Rothenberger, Aribert Kuntsi, Jonna Oades, Robert D. Banaschewski, Tobias Franke, Barbara Buitelaar, Jan K. Arias Vasquez, Alejandro Doyle, Alysa E. Reif, Andreas Lesch, Klaus-Peter Freitag, Christine Rivero, Olga Palmason, Haukur Romanos, Marcel Langley, Kate Rietschel, Marcella Witt, Stephanie H. Dalsgaard, Soeren Børglum, Anders D. Waldman, Irwin Wilmot, Beth Molly, Nikolas Bau, Claiton H.D. Crosbie, Jennifer Schachar, Russell Loo, Sandra K. McGough, James J. Grevet, Eugenio H. Medland, Sarah E. Robinson, Elise Weiss, Lauren A. Bacchelli, Elena Bailey, Anthony Bal, Vanessa Battaglia, Agatino Betancur, Catalina Bolton, Patrick Cantor, Rita Celestino-Soper, Patrícia Dawson, Geraldine De Rubeis, Silvia Duque, Frederico Green, Andrew Klauck, Sabine M. Leboyer, Marion Levitt, Pat Maestrini, Elena Mane, Shrikant De-Luca, Daniel Moreno- Parr, Jeremy Regan, Regina Reichenberg, Abraham Sandin, Sven Vorstman, Jacob Wassink, Thomas Wijsman, Ellen Cook, Edwin Santangelo, Susan Delorme, Richard Rogé, Bernadette Magalhaes, Tiago Arking, Dan Schulze, Thomas G. Thompson, Robert C. Strohmaier, Jana Matthews, Keith Melle, Ingrid Morris, Derek Blackwood, Douglas McIntosh, Andrew Bergen, Sarah E Schalling, Martin Jamain, Stéphane Maaser, Anna Fischer, Sascha B. Reinbold, Céline S. Fullerton, Janice M. Guzman-Parra, José Mayoral, Fermin Schofield, Peter R. Cichon, Sven Mühleisen, Thomas W. Degenhardt, Franziska Schumacher, Johannes Bauer, Michael Mitchell, Philip B. Gershon, Elliot S. Rice, John Potash, James B. Zandi, Peter P. Craddock, Nick Ferrier, I. Nicol Alda, Martin Rouleau, Guy A. Turecki, Gustavo Ophoff, Roel Pato, Carlos Anjorin, Adebayo Stahl, Eli Leber, Markus Czerski, Piotr M. Cruceanu, Cristiana Jones, Ian R. Posthuma, Danielle Andlauer, Till F.M. Forstner, Andreas J. Streit, Fabian Baune, Bernhard T. Air, Tracy Sinnamon, Grant Wray, Naomi R. MacIntyre, Donald J. Porteous, David Homuth, Georg Rivera, Margarita Grove, Jakob Middeldorp, Christel M. Hickie, Ian Pergadia, Michele Mehta, Divya Smit, Johannes H. Jansen, Rick de Geus, Eco Dunn, Erin Li, Qingqin S. Nauck, Matthias Schoevers, Robert A. Beekman, Aartjan TF Knowles, James A. Viktorin, Alexander Arnold, Paul Barr, Cathy L. Bedoya-Berrio, Gabriel Bienvenu, O. Joseph Brentani, Helena Burton, Christie Camarena, Beatriz Cappi, Carolina Cath, Danielle Cavallini, Maria Cusi, Daniele Darrow, Sabrina Denys, Damiaan Derks, Eske M. Dietrich, Andrea Fernandez, Thomas Figee, Martijn Freimer, Nelson Gerber, Gloria Grados, Marco Greenberg, Erica Hanna, Gregory L. Hartmann, Andreas Hirschtritt, Matthew E. Hoekstra, Pieter J. Huang, Alden Huyser, Chaim Illmann, Cornelia Jenike, Michael Kuperman, Samuel Leventhal, Bennett Lochner, Christine Lyon, Gholson J. Macciardi, Fabio Madruga-Garrido, Marcos Malaty, Irene A. Maras, Athanasios McGrath, Lauren Miguel, Eurípedes C. Mir, Pablo Nestadt, Gerald Nicolini, Humberto Okun, Michael S. Pakstis, Andrew Paschou, Peristera Piacentini, John Pittenger, Christopher Plessen, Kerstin Ramensky, Vasily Ramos, Eliana M. Reus, Victor Richter, Margaret A. Riddle, Mark A. Robertson, Mary M. Roessner, Veit Rosário, Maria Samuels, Jack F. Sandor, Paul Stein, Dan J. Tsetsos, Fotis Van Nieuwerburgh, Filip Weatherall, Sarah Wendland, Jens R. Wolanczyk, Tomasz Worbe, Yulia Zai, Gwyneth Goes, Fernando S. McLaughlin, Nicole Nestadt, Paul S. Grabe, Hans-Jorgen Depienne, Christel Konkashbaev, Anuar Lanzagorta, Nuria Valencia-Duarte, Ana Bramon, Elvira Buccola, Nancy Cahn, Wiepke Cairns, Murray Chong, Siow A. Cohen, David Crespo-Facorro, Benedicto Crowley, James Davidson, Michael DeLisi, Lynn Dinan, Timothy Donohoe, Gary Drapeau, Elodie Duan, Jubao Haan, Lieuwe Hougaard, David Karachanak-Yankova, Sena Khrunin, Andrey Klovins, Janis Kučinskas, Vaidutis Lee Chee Keong, Jimmy Limborska, Svetlana Loughland, Carmel Lönnqvist, Jouko Maher, Brion Mattheisen, Manuel McDonald, Colm Murphy, Kieran C. Nenadic, Igor van Os, Jim Pantelis, Christos Pato, Michele Petryshen, Tracey Quested, Digby Roussos, Panos Sanders, Alan R. Schall, Ulrich Schwab, Sibylle G. Sim, Kang So, Hon-Cheong Stögmann, Elisabeth Subramaniam, Mythily Toncheva, Draga Waddington, John Walters, James Weiser, Mark Cheng, Wei Cloninger, Robert Curtis, David Gejman, Pablo V. Henskens, Frans Mattingsdal, Morten Oh, Sang-Yun Scott, Rodney Webb, Bradley Breen, Gerome Churchhouse, Claire Bulik, Cynthia M. Daly, Mark Dichgans, Martin Faraone, Stephen V. Guerreiro, Rita Holmans, Peter Kendler, Kenneth S. Koeleman, Bobby Mathews, Carol A. Price, Alkes Scharf, Jeremiah Sklar, Pamela Williams, Julie Wood, Nicholas W. Cotsapas, Chris Palotie, Aarno Smoller, Jordan W. Sullivan, Patrick Rosand, Jonathan Corvin, Aiden Neale, Benjamin M. |
| author_sort | Anttila, Verneri |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap.We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology. |
| first_indexed | 2025-11-14T20:25:22Z |
| format | Article |
| id | nottingham-52705 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:25:22Z |
| publishDate | 2018 |
| publisher | American Association for the Advancement of Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-527052020-05-04T19:42:03Z https://eprints.nottingham.ac.uk/52705/ Analysis of shared heritability in common disorders of the brain Anttila, Verneri Bulik-Sullivan, Brendan Finucane, Hilary K. Walters, Raymond K. Bras, Jose Duncan, Laramie Escott-Price, Valentina Falcone, Guido J. Gormley, Padhraig Malik, Rainer Patsopoulos, Nikolaos A. Ripke, Stephan Wei, Zhi Yu, Dongmei Lee, Phil H. Turley, Patrick Grenier-Boley, Benjamin Chouraki, Vincent Kamatani, Yoichiro Berr, Claudine Letenneur, Luc Hannequin, Didier Amouyel, Philippe Boland, Anne Deleuze, Jean-François Duron, Emmanuelle Vardarajan, Badri N. Reitz, Christiane Goate, Alison M. Huentelman, Matthew J. Kamboh, M. Ilyas Larson, Eric B. Rogaeva, Ekaterina St George-Hyslop, Peter Hakonarson, Hakon Kukull, Walter A. Farrer, Lindsay A. Barnes, Lisa L. Beach, Thomas G. Demirci, F. Yesim Head, Elizabeth Hulette, Christine M. Jicha, Gregory A. Kauwe, John S.K. Kaye, Jeffrey A. Leverenz, James B. Levey, Allan I. Lieberman, Andrew P. Pankratz, Vernon S. Poon, Wayne W. Quinn, Joseph F. Saykin, Andrew J. Schneider, Lon S. Smith, Amanda G. Sonnen, Joshua A. Stern, Robert A. Van Deerlin, Vivianna M. Van Eldik, Linda J. Harold, Denise Russo, Giancarlo Rubinsztein, David C. Bayer, Anthony Tsolaki, Magda Proitsi, Petra Fox, Nick C. Hampel, Harald Owen, Michael J. Mead, Simon Passmore, Peter Morgan, Kevin Nöthen, Markus M. Rossor, Martin Lupton, Michelle K. Hoffmann, Per Kornhuber, Johannes Lawlor, Brian McQuillin, Andrew Al-Chalabi, Ammar Bis, Joshua C Ruiz, Agustin Boada, Mercè Seshadri, Sudha Beiser, Alexa Rice, Kenneth van der Lee, Sven J. De Jager, Philip L. Geschwind, Daniel H. Riemenschneider, Matthias Riedel-Heller, Steffi Rotter, Jerome I Ransmayr, Gerhard Hyman, Bradley T. Cruchaga, Carlos Alegret, Montserrat Winsvold, Bendik Palta, Priit Farh, Kai-How Cuenca-Leon, Ester Furlotte, Nicholas Kurth, Tobias Ligthart, Lannie Terwindt, Gisela M. Freilinger, Tobias Ran, Caroline Gordon, Scott D. Borck, Guntram Adams, Hieab H.H. Lehtimäki, Terho Wedenoja, Juho Buring, Julie E. Schürks, Markus Hrafnsdottir, Maria Hottenga, Jouke-Jan Penninx, Brenda Artto, Ville Kaunisto, Mari Vepsäläinen, Salli Martin, Nicholas G. Montgomery, Grant W. Kurki, Mitja I. Hämäläinen, Eija Huang, Hailiang Huang, Jie Sandor, Cynthia Webber, Caleb Muller-Myhsok, Bertram Schreiber, Stefan Salomaa, Veikko Loehrer, Elizabeth Göbel, Hartmut Macaya, Alfons Pozo-Rosich, Patricia Hansen, Thomas Werge, Thomas Kaprio, Jaakko Metspalu, Andres Kubisch, Christian Ferrari, Michel D. Belin, Andrea C. van den Maagdenberg, Arn M.J.M. Zwart, John-Anker Boomsma, Dorret Eriksson, Nicholas Olesen, Jes Chasman, Daniel I. Nyholt, Dale R. Avbersek, Andreja Baum, Larry Berkovic, Samuel Bradfield, Jonathan Buono, Russell Catarino, Claudia B. Cossette, Patrick De Jonghe, Peter Depondt, Chantal Dlugos, Dennis Ferraro, Thomas N. French, Jacqueline Hjalgrim, Helle Jamnadas-Khoda, Jennifer Kälviäinen, Reetta Kunz, Wolfram S. Lerche, Holger Leu, Costin Lindhout, Dick Lo, Warren Lowenstein, Daniel McCormack, Mark Møller, Rikke S. Molloy, Anne Ng, Ping-Wing Oliver, Karen Privitera, Michael Radtke, Rodney Ruppert, Ann-Kathrin Sander, Thomas Schachter, Steven Schankin, Christoph Scheffer, Ingrid Schoch, Susanne Sisodiya, Sanjay M. Smith, Philip Sperling, Michael Striano, Pasquale Surges, Rainer Thomas, G. Neil Visscher, Frank Whelan, Christopher D. Zara, Federico Heinzen, Erin L. Marson, Anthony Becker, Felicitas Stroink, Hans Zimprich, Fritz Gasser, Thomas Gibbs, Raphael Heutink, Peter Martinez, Maria Morris, Huw R. Sharma, Manu Ryten, Mina Mok, Kin Y. Pulit, Sara Bevan, Steve Holliday, Elizabeth Attia, John Battey, Thomas Boncoraglio, Giorgio Thijs, Vincent Chen, Wei-Min Mitchell, Braxton Rothwell, Peter Sharma, Pankaj Sudlow, Cathie Vicente, Astrid Markus, Hugh Kourkoulis, Christina Pera, Joana Raffeld, Miriam Silliman, Scott Boraska Perica, Vesna Thornton, Laura M. Huckins, Laura M. William Rayner, N. Lewis, Cathryn M. Gratacos, Monica Rybakowski, Filip Keski-Rahkonen, Anna Raevuori, Anu Hudson, James I. Reichborn-Kjennerud, Ted Monteleone, Palmiero Karwautz, Andreas Mannik, Katrin Baker, Jessica H. O’Toole, Julie K. Trace, Sara E. Davis, Oliver S. P. Helder, Sietske G. Ehrlich, Stefan Herpertz-Dahlmann, Beate Danner, Unna N. van Elburg, Annemarie A. Clementi, Maurizio Forzan, Monica Docampo, Elisa Lissowska, Jolanta Hauser, Joanna Tortorella, Alfonso Maj, Mario Gonidakis, Fragiskos Tziouvas, Konstantinos Papezova, Hana Yilmaz, Zeynep Wagner, Gudrun Cohen-Woods, Sarah Herms, Stefan Julià, Antonio Rabionet, Raquel Dick, Danielle M. Ripatti, Samuli Andreassen, Ole A. Espeseth, Thomas Lundervold, Astri J. Steen, Vidar M. Pinto, Dalila Scherer, Stephen W. Aschauer, Harald Schosser, Alexandra Alfredsson, Lars Padyukov, Leonid Halmi, Katherine A. Mitchell, James Strober, Michael Bergen, Andrew W. Kaye, Walter Szatkiewicz, Jin Peng Cormand, Bru Ramos-Quiroga, Josep Antoni Sánchez-Mora, Cristina Ribasés, Marta Casas, Miguel Hervas, Amaia Arranz, Maria Jesús Haavik, Jan Zayats, Tetyana Johansson, Stefan Williams, Nigel Dempfle, Astrid Rothenberger, Aribert Kuntsi, Jonna Oades, Robert D. Banaschewski, Tobias Franke, Barbara Buitelaar, Jan K. Arias Vasquez, Alejandro Doyle, Alysa E. Reif, Andreas Lesch, Klaus-Peter Freitag, Christine Rivero, Olga Palmason, Haukur Romanos, Marcel Langley, Kate Rietschel, Marcella Witt, Stephanie H. Dalsgaard, Soeren Børglum, Anders D. Waldman, Irwin Wilmot, Beth Molly, Nikolas Bau, Claiton H.D. Crosbie, Jennifer Schachar, Russell Loo, Sandra K. McGough, James J. Grevet, Eugenio H. Medland, Sarah E. Robinson, Elise Weiss, Lauren A. Bacchelli, Elena Bailey, Anthony Bal, Vanessa Battaglia, Agatino Betancur, Catalina Bolton, Patrick Cantor, Rita Celestino-Soper, Patrícia Dawson, Geraldine De Rubeis, Silvia Duque, Frederico Green, Andrew Klauck, Sabine M. Leboyer, Marion Levitt, Pat Maestrini, Elena Mane, Shrikant De-Luca, Daniel Moreno- Parr, Jeremy Regan, Regina Reichenberg, Abraham Sandin, Sven Vorstman, Jacob Wassink, Thomas Wijsman, Ellen Cook, Edwin Santangelo, Susan Delorme, Richard Rogé, Bernadette Magalhaes, Tiago Arking, Dan Schulze, Thomas G. Thompson, Robert C. Strohmaier, Jana Matthews, Keith Melle, Ingrid Morris, Derek Blackwood, Douglas McIntosh, Andrew Bergen, Sarah E Schalling, Martin Jamain, Stéphane Maaser, Anna Fischer, Sascha B. Reinbold, Céline S. Fullerton, Janice M. Guzman-Parra, José Mayoral, Fermin Schofield, Peter R. Cichon, Sven Mühleisen, Thomas W. Degenhardt, Franziska Schumacher, Johannes Bauer, Michael Mitchell, Philip B. Gershon, Elliot S. Rice, John Potash, James B. Zandi, Peter P. Craddock, Nick Ferrier, I. Nicol Alda, Martin Rouleau, Guy A. Turecki, Gustavo Ophoff, Roel Pato, Carlos Anjorin, Adebayo Stahl, Eli Leber, Markus Czerski, Piotr M. Cruceanu, Cristiana Jones, Ian R. Posthuma, Danielle Andlauer, Till F.M. Forstner, Andreas J. Streit, Fabian Baune, Bernhard T. Air, Tracy Sinnamon, Grant Wray, Naomi R. MacIntyre, Donald J. Porteous, David Homuth, Georg Rivera, Margarita Grove, Jakob Middeldorp, Christel M. Hickie, Ian Pergadia, Michele Mehta, Divya Smit, Johannes H. Jansen, Rick de Geus, Eco Dunn, Erin Li, Qingqin S. Nauck, Matthias Schoevers, Robert A. Beekman, Aartjan TF Knowles, James A. Viktorin, Alexander Arnold, Paul Barr, Cathy L. Bedoya-Berrio, Gabriel Bienvenu, O. Joseph Brentani, Helena Burton, Christie Camarena, Beatriz Cappi, Carolina Cath, Danielle Cavallini, Maria Cusi, Daniele Darrow, Sabrina Denys, Damiaan Derks, Eske M. Dietrich, Andrea Fernandez, Thomas Figee, Martijn Freimer, Nelson Gerber, Gloria Grados, Marco Greenberg, Erica Hanna, Gregory L. Hartmann, Andreas Hirschtritt, Matthew E. Hoekstra, Pieter J. Huang, Alden Huyser, Chaim Illmann, Cornelia Jenike, Michael Kuperman, Samuel Leventhal, Bennett Lochner, Christine Lyon, Gholson J. Macciardi, Fabio Madruga-Garrido, Marcos Malaty, Irene A. Maras, Athanasios McGrath, Lauren Miguel, Eurípedes C. Mir, Pablo Nestadt, Gerald Nicolini, Humberto Okun, Michael S. Pakstis, Andrew Paschou, Peristera Piacentini, John Pittenger, Christopher Plessen, Kerstin Ramensky, Vasily Ramos, Eliana M. Reus, Victor Richter, Margaret A. Riddle, Mark A. Robertson, Mary M. Roessner, Veit Rosário, Maria Samuels, Jack F. Sandor, Paul Stein, Dan J. Tsetsos, Fotis Van Nieuwerburgh, Filip Weatherall, Sarah Wendland, Jens R. Wolanczyk, Tomasz Worbe, Yulia Zai, Gwyneth Goes, Fernando S. McLaughlin, Nicole Nestadt, Paul S. Grabe, Hans-Jorgen Depienne, Christel Konkashbaev, Anuar Lanzagorta, Nuria Valencia-Duarte, Ana Bramon, Elvira Buccola, Nancy Cahn, Wiepke Cairns, Murray Chong, Siow A. Cohen, David Crespo-Facorro, Benedicto Crowley, James Davidson, Michael DeLisi, Lynn Dinan, Timothy Donohoe, Gary Drapeau, Elodie Duan, Jubao Haan, Lieuwe Hougaard, David Karachanak-Yankova, Sena Khrunin, Andrey Klovins, Janis Kučinskas, Vaidutis Lee Chee Keong, Jimmy Limborska, Svetlana Loughland, Carmel Lönnqvist, Jouko Maher, Brion Mattheisen, Manuel McDonald, Colm Murphy, Kieran C. Nenadic, Igor van Os, Jim Pantelis, Christos Pato, Michele Petryshen, Tracey Quested, Digby Roussos, Panos Sanders, Alan R. Schall, Ulrich Schwab, Sibylle G. Sim, Kang So, Hon-Cheong Stögmann, Elisabeth Subramaniam, Mythily Toncheva, Draga Waddington, John Walters, James Weiser, Mark Cheng, Wei Cloninger, Robert Curtis, David Gejman, Pablo V. Henskens, Frans Mattingsdal, Morten Oh, Sang-Yun Scott, Rodney Webb, Bradley Breen, Gerome Churchhouse, Claire Bulik, Cynthia M. Daly, Mark Dichgans, Martin Faraone, Stephen V. Guerreiro, Rita Holmans, Peter Kendler, Kenneth S. Koeleman, Bobby Mathews, Carol A. Price, Alkes Scharf, Jeremiah Sklar, Pamela Williams, Julie Wood, Nicholas W. Cotsapas, Chris Palotie, Aarno Smoller, Jordan W. Sullivan, Patrick Rosand, Jonathan Corvin, Aiden Neale, Benjamin M. Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap.We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology. American Association for the Advancement of Science 2018-06-22 Article PeerReviewed Anttila, Verneri, Bulik-Sullivan, Brendan, Finucane, Hilary K., Walters, Raymond K., Bras, Jose, Duncan, Laramie, Escott-Price, Valentina, Falcone, Guido J., Gormley, Padhraig, Malik, Rainer, Patsopoulos, Nikolaos A., Ripke, Stephan, Wei, Zhi, Yu, Dongmei, Lee, Phil H., Turley, Patrick, Grenier-Boley, Benjamin, Chouraki, Vincent, Kamatani, Yoichiro, Berr, Claudine, Letenneur, Luc, Hannequin, Didier, Amouyel, Philippe, Boland, Anne, Deleuze, Jean-François, Duron, Emmanuelle, Vardarajan, Badri N., Reitz, Christiane, Goate, Alison M., Huentelman, Matthew J., Kamboh, M. Ilyas, Larson, Eric B., Rogaeva, Ekaterina, St George-Hyslop, Peter, Hakonarson, Hakon, Kukull, Walter A., Farrer, Lindsay A., Barnes, Lisa L., Beach, Thomas G., Demirci, F. 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(2018) Analysis of shared heritability in common disorders of the brain. Science, 360 (6395). eaap8757. ISSN 0036-8075 http://dx.doi.org/10.1126/science.aap8757 doi:10.1126/science.aap8757 doi:10.1126/science.aap8757 |
| spellingShingle | Anttila, Verneri Bulik-Sullivan, Brendan Finucane, Hilary K. Walters, Raymond K. Bras, Jose Duncan, Laramie Escott-Price, Valentina Falcone, Guido J. Gormley, Padhraig Malik, Rainer Patsopoulos, Nikolaos A. Ripke, Stephan Wei, Zhi Yu, Dongmei Lee, Phil H. Turley, Patrick Grenier-Boley, Benjamin Chouraki, Vincent Kamatani, Yoichiro Berr, Claudine Letenneur, Luc Hannequin, Didier Amouyel, Philippe Boland, Anne Deleuze, Jean-François Duron, Emmanuelle Vardarajan, Badri N. Reitz, Christiane Goate, Alison M. Huentelman, Matthew J. Kamboh, M. Ilyas Larson, Eric B. Rogaeva, Ekaterina St George-Hyslop, Peter Hakonarson, Hakon Kukull, Walter A. Farrer, Lindsay A. Barnes, Lisa L. Beach, Thomas G. Demirci, F. Yesim Head, Elizabeth Hulette, Christine M. Jicha, Gregory A. Kauwe, John S.K. Kaye, Jeffrey A. Leverenz, James B. Levey, Allan I. Lieberman, Andrew P. Pankratz, Vernon S. Poon, Wayne W. Quinn, Joseph F. Saykin, Andrew J. Schneider, Lon S. Smith, Amanda G. Sonnen, Joshua A. Stern, Robert A. Van Deerlin, Vivianna M. Van Eldik, Linda J. Harold, Denise Russo, Giancarlo Rubinsztein, David C. Bayer, Anthony Tsolaki, Magda Proitsi, Petra Fox, Nick C. Hampel, Harald Owen, Michael J. Mead, Simon Passmore, Peter Morgan, Kevin Nöthen, Markus M. Rossor, Martin Lupton, Michelle K. Hoffmann, Per Kornhuber, Johannes Lawlor, Brian McQuillin, Andrew Al-Chalabi, Ammar Bis, Joshua C Ruiz, Agustin Boada, Mercè Seshadri, Sudha Beiser, Alexa Rice, Kenneth van der Lee, Sven J. De Jager, Philip L. Geschwind, Daniel H. Riemenschneider, Matthias Riedel-Heller, Steffi Rotter, Jerome I Ransmayr, Gerhard Hyman, Bradley T. Cruchaga, Carlos Alegret, Montserrat Winsvold, Bendik Palta, Priit Farh, Kai-How Cuenca-Leon, Ester Furlotte, Nicholas Kurth, Tobias Ligthart, Lannie Terwindt, Gisela M. Freilinger, Tobias Ran, Caroline Gordon, Scott D. Borck, Guntram Adams, Hieab H.H. Lehtimäki, Terho Wedenoja, Juho Buring, Julie E. Schürks, Markus Hrafnsdottir, Maria Hottenga, Jouke-Jan Penninx, Brenda Artto, Ville Kaunisto, Mari Vepsäläinen, Salli Martin, Nicholas G. Montgomery, Grant W. Kurki, Mitja I. Hämäläinen, Eija Huang, Hailiang Huang, Jie Sandor, Cynthia Webber, Caleb Muller-Myhsok, Bertram Schreiber, Stefan Salomaa, Veikko Loehrer, Elizabeth Göbel, Hartmut Macaya, Alfons Pozo-Rosich, Patricia Hansen, Thomas Werge, Thomas Kaprio, Jaakko Metspalu, Andres Kubisch, Christian Ferrari, Michel D. Belin, Andrea C. van den Maagdenberg, Arn M.J.M. Zwart, John-Anker Boomsma, Dorret Eriksson, Nicholas Olesen, Jes Chasman, Daniel I. Nyholt, Dale R. Avbersek, Andreja Baum, Larry Berkovic, Samuel Bradfield, Jonathan Buono, Russell Catarino, Claudia B. Cossette, Patrick De Jonghe, Peter Depondt, Chantal Dlugos, Dennis Ferraro, Thomas N. French, Jacqueline Hjalgrim, Helle Jamnadas-Khoda, Jennifer Kälviäinen, Reetta Kunz, Wolfram S. Lerche, Holger Leu, Costin Lindhout, Dick Lo, Warren Lowenstein, Daniel McCormack, Mark Møller, Rikke S. Molloy, Anne Ng, Ping-Wing Oliver, Karen Privitera, Michael Radtke, Rodney Ruppert, Ann-Kathrin Sander, Thomas Schachter, Steven Schankin, Christoph Scheffer, Ingrid Schoch, Susanne Sisodiya, Sanjay M. Smith, Philip Sperling, Michael Striano, Pasquale Surges, Rainer Thomas, G. Neil Visscher, Frank Whelan, Christopher D. Zara, Federico Heinzen, Erin L. Marson, Anthony Becker, Felicitas Stroink, Hans Zimprich, Fritz Gasser, Thomas Gibbs, Raphael Heutink, Peter Martinez, Maria Morris, Huw R. Sharma, Manu Ryten, Mina Mok, Kin Y. Pulit, Sara Bevan, Steve Holliday, Elizabeth Attia, John Battey, Thomas Boncoraglio, Giorgio Thijs, Vincent Chen, Wei-Min Mitchell, Braxton Rothwell, Peter Sharma, Pankaj Sudlow, Cathie Vicente, Astrid Markus, Hugh Kourkoulis, Christina Pera, Joana Raffeld, Miriam Silliman, Scott Boraska Perica, Vesna Thornton, Laura M. Huckins, Laura M. William Rayner, N. Lewis, Cathryn M. Gratacos, Monica Rybakowski, Filip Keski-Rahkonen, Anna Raevuori, Anu Hudson, James I. Reichborn-Kjennerud, Ted Monteleone, Palmiero Karwautz, Andreas Mannik, Katrin Baker, Jessica H. O’Toole, Julie K. Trace, Sara E. Davis, Oliver S. P. Helder, Sietske G. Ehrlich, Stefan Herpertz-Dahlmann, Beate Danner, Unna N. van Elburg, Annemarie A. Clementi, Maurizio Forzan, Monica Docampo, Elisa Lissowska, Jolanta Hauser, Joanna Tortorella, Alfonso Maj, Mario Gonidakis, Fragiskos Tziouvas, Konstantinos Papezova, Hana Yilmaz, Zeynep Wagner, Gudrun Cohen-Woods, Sarah Herms, Stefan Julià, Antonio Rabionet, Raquel Dick, Danielle M. Ripatti, Samuli Andreassen, Ole A. Espeseth, Thomas Lundervold, Astri J. Steen, Vidar M. Pinto, Dalila Scherer, Stephen W. Aschauer, Harald Schosser, Alexandra Alfredsson, Lars Padyukov, Leonid Halmi, Katherine A. Mitchell, James Strober, Michael Bergen, Andrew W. Kaye, Walter Szatkiewicz, Jin Peng Cormand, Bru Ramos-Quiroga, Josep Antoni Sánchez-Mora, Cristina Ribasés, Marta Casas, Miguel Hervas, Amaia Arranz, Maria Jesús Haavik, Jan Zayats, Tetyana Johansson, Stefan Williams, Nigel Dempfle, Astrid Rothenberger, Aribert Kuntsi, Jonna Oades, Robert D. Banaschewski, Tobias Franke, Barbara Buitelaar, Jan K. Arias Vasquez, Alejandro Doyle, Alysa E. Reif, Andreas Lesch, Klaus-Peter Freitag, Christine Rivero, Olga Palmason, Haukur Romanos, Marcel Langley, Kate Rietschel, Marcella Witt, Stephanie H. Dalsgaard, Soeren Børglum, Anders D. Waldman, Irwin Wilmot, Beth Molly, Nikolas Bau, Claiton H.D. Crosbie, Jennifer Schachar, Russell Loo, Sandra K. McGough, James J. Grevet, Eugenio H. Medland, Sarah E. Robinson, Elise Weiss, Lauren A. Bacchelli, Elena Bailey, Anthony Bal, Vanessa Battaglia, Agatino Betancur, Catalina Bolton, Patrick Cantor, Rita Celestino-Soper, Patrícia Dawson, Geraldine De Rubeis, Silvia Duque, Frederico Green, Andrew Klauck, Sabine M. Leboyer, Marion Levitt, Pat Maestrini, Elena Mane, Shrikant De-Luca, Daniel Moreno- Parr, Jeremy Regan, Regina Reichenberg, Abraham Sandin, Sven Vorstman, Jacob Wassink, Thomas Wijsman, Ellen Cook, Edwin Santangelo, Susan Delorme, Richard Rogé, Bernadette Magalhaes, Tiago Arking, Dan Schulze, Thomas G. Thompson, Robert C. Strohmaier, Jana Matthews, Keith Melle, Ingrid Morris, Derek Blackwood, Douglas McIntosh, Andrew Bergen, Sarah E Schalling, Martin Jamain, Stéphane Maaser, Anna Fischer, Sascha B. Reinbold, Céline S. Fullerton, Janice M. Guzman-Parra, José Mayoral, Fermin Schofield, Peter R. Cichon, Sven Mühleisen, Thomas W. Degenhardt, Franziska Schumacher, Johannes Bauer, Michael Mitchell, Philip B. Gershon, Elliot S. Rice, John Potash, James B. Zandi, Peter P. Craddock, Nick Ferrier, I. Nicol Alda, Martin Rouleau, Guy A. Turecki, Gustavo Ophoff, Roel Pato, Carlos Anjorin, Adebayo Stahl, Eli Leber, Markus Czerski, Piotr M. Cruceanu, Cristiana Jones, Ian R. Posthuma, Danielle Andlauer, Till F.M. Forstner, Andreas J. Streit, Fabian Baune, Bernhard T. Air, Tracy Sinnamon, Grant Wray, Naomi R. MacIntyre, Donald J. Porteous, David Homuth, Georg Rivera, Margarita Grove, Jakob Middeldorp, Christel M. Hickie, Ian Pergadia, Michele Mehta, Divya Smit, Johannes H. Jansen, Rick de Geus, Eco Dunn, Erin Li, Qingqin S. Nauck, Matthias Schoevers, Robert A. Beekman, Aartjan TF Knowles, James A. Viktorin, Alexander Arnold, Paul Barr, Cathy L. Bedoya-Berrio, Gabriel Bienvenu, O. Joseph Brentani, Helena Burton, Christie Camarena, Beatriz Cappi, Carolina Cath, Danielle Cavallini, Maria Cusi, Daniele Darrow, Sabrina Denys, Damiaan Derks, Eske M. Dietrich, Andrea Fernandez, Thomas Figee, Martijn Freimer, Nelson Gerber, Gloria Grados, Marco Greenberg, Erica Hanna, Gregory L. Hartmann, Andreas Hirschtritt, Matthew E. Hoekstra, Pieter J. Huang, Alden Huyser, Chaim Illmann, Cornelia Jenike, Michael Kuperman, Samuel Leventhal, Bennett Lochner, Christine Lyon, Gholson J. Macciardi, Fabio Madruga-Garrido, Marcos Malaty, Irene A. Maras, Athanasios McGrath, Lauren Miguel, Eurípedes C. Mir, Pablo Nestadt, Gerald Nicolini, Humberto Okun, Michael S. Pakstis, Andrew Paschou, Peristera Piacentini, John Pittenger, Christopher Plessen, Kerstin Ramensky, Vasily Ramos, Eliana M. Reus, Victor Richter, Margaret A. Riddle, Mark A. Robertson, Mary M. Roessner, Veit Rosário, Maria Samuels, Jack F. Sandor, Paul Stein, Dan J. Tsetsos, Fotis Van Nieuwerburgh, Filip Weatherall, Sarah Wendland, Jens R. Wolanczyk, Tomasz Worbe, Yulia Zai, Gwyneth Goes, Fernando S. McLaughlin, Nicole Nestadt, Paul S. Grabe, Hans-Jorgen Depienne, Christel Konkashbaev, Anuar Lanzagorta, Nuria Valencia-Duarte, Ana Bramon, Elvira Buccola, Nancy Cahn, Wiepke Cairns, Murray Chong, Siow A. Cohen, David Crespo-Facorro, Benedicto Crowley, James Davidson, Michael DeLisi, Lynn Dinan, Timothy Donohoe, Gary Drapeau, Elodie Duan, Jubao Haan, Lieuwe Hougaard, David Karachanak-Yankova, Sena Khrunin, Andrey Klovins, Janis Kučinskas, Vaidutis Lee Chee Keong, Jimmy Limborska, Svetlana Loughland, Carmel Lönnqvist, Jouko Maher, Brion Mattheisen, Manuel McDonald, Colm Murphy, Kieran C. Nenadic, Igor van Os, Jim Pantelis, Christos Pato, Michele Petryshen, Tracey Quested, Digby Roussos, Panos Sanders, Alan R. Schall, Ulrich Schwab, Sibylle G. Sim, Kang So, Hon-Cheong Stögmann, Elisabeth Subramaniam, Mythily Toncheva, Draga Waddington, John Walters, James Weiser, Mark Cheng, Wei Cloninger, Robert Curtis, David Gejman, Pablo V. Henskens, Frans Mattingsdal, Morten Oh, Sang-Yun Scott, Rodney Webb, Bradley Breen, Gerome Churchhouse, Claire Bulik, Cynthia M. Daly, Mark Dichgans, Martin Faraone, Stephen V. Guerreiro, Rita Holmans, Peter Kendler, Kenneth S. Koeleman, Bobby Mathews, Carol A. Price, Alkes Scharf, Jeremiah Sklar, Pamela Williams, Julie Wood, Nicholas W. Cotsapas, Chris Palotie, Aarno Smoller, Jordan W. Sullivan, Patrick Rosand, Jonathan Corvin, Aiden Neale, Benjamin M. Analysis of shared heritability in common disorders of the brain |
| title | Analysis of shared heritability in common disorders of the brain |
| title_full | Analysis of shared heritability in common disorders of the brain |
| title_fullStr | Analysis of shared heritability in common disorders of the brain |
| title_full_unstemmed | Analysis of shared heritability in common disorders of the brain |
| title_short | Analysis of shared heritability in common disorders of the brain |
| title_sort | analysis of shared heritability in common disorders of the brain |
| url | https://eprints.nottingham.ac.uk/52705/ https://eprints.nottingham.ac.uk/52705/ https://eprints.nottingham.ac.uk/52705/ |