Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations
Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables gove...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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Nature Publishing Group
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52610/ |
| _version_ | 1848798766994292736 |
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| author | Garcia-Gonzalez, Daniel Race, Nicholas S. Voets, Natalie L. Jenkins, Damian R. Sotiropoulos, Stamatios N. Acosta, Glen Cruz-Haces, Marcela Tang, Jonathan Shi, Riyi Jérusalem, Antoine |
| author_facet | Garcia-Gonzalez, Daniel Race, Nicholas S. Voets, Natalie L. Jenkins, Damian R. Sotiropoulos, Stamatios N. Acosta, Glen Cruz-Haces, Marcela Tang, Jonathan Shi, Riyi Jérusalem, Antoine |
| author_sort | Garcia-Gonzalez, Daniel |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue damage eventually cascading into cognitive deficits, we performed a study on the mechanics of rat brain under blast conditions. To this end, experiments were carried out to analyse and correlate post-injury oxidative stress distribution with cognitive deficits on a live rat exposed to blast. A computational model of the rat head was developed from imaging data and validated against in vivo brain displacement measurements. The blast event was reconstructed in silico to provide mechanistic thresholds that best correlate with cognitive damage at the regional neuronal tissue level, irrespectively of the shape or size of the brain tissue types. This approach was leveraged on a human head model where the prediction of cognitive deficits was shown to correlate with literature findings. The mechanistic insights from this work were finally used to propose a novel helmet design roadmap and potential avenues for therapeutic innovations against blast traumatic brain injury. |
| first_indexed | 2025-11-14T20:25:00Z |
| format | Article |
| id | nottingham-52610 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:25:00Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-526102020-05-04T19:45:25Z https://eprints.nottingham.ac.uk/52610/ Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations Garcia-Gonzalez, Daniel Race, Nicholas S. Voets, Natalie L. Jenkins, Damian R. Sotiropoulos, Stamatios N. Acosta, Glen Cruz-Haces, Marcela Tang, Jonathan Shi, Riyi Jérusalem, Antoine Blast-induced traumatic brain injury has been associated with neurodegenerative and neuropsychiatric disorders. To date, although damage due to oxidative stress appears to be important, the specific mechanistic causes of such disorders remain elusive. Here, to determine the mechanical variables governing the tissue damage eventually cascading into cognitive deficits, we performed a study on the mechanics of rat brain under blast conditions. To this end, experiments were carried out to analyse and correlate post-injury oxidative stress distribution with cognitive deficits on a live rat exposed to blast. A computational model of the rat head was developed from imaging data and validated against in vivo brain displacement measurements. The blast event was reconstructed in silico to provide mechanistic thresholds that best correlate with cognitive damage at the regional neuronal tissue level, irrespectively of the shape or size of the brain tissue types. This approach was leveraged on a human head model where the prediction of cognitive deficits was shown to correlate with literature findings. The mechanistic insights from this work were finally used to propose a novel helmet design roadmap and potential avenues for therapeutic innovations against blast traumatic brain injury. Nature Publishing Group 2018-07-06 Article PeerReviewed Garcia-Gonzalez, Daniel, Race, Nicholas S., Voets, Natalie L., Jenkins, Damian R., Sotiropoulos, Stamatios N., Acosta, Glen, Cruz-Haces, Marcela, Tang, Jonathan, Shi, Riyi and Jérusalem, Antoine (2018) Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations. Scientific Reports, 8 . 10273/1-10273/14. ISSN 2045-2322 https://www.nature.com/articles/s41598-018-28271-7 doi:10.1038/s41598-018-28271-7 doi:10.1038/s41598-018-28271-7 |
| spellingShingle | Garcia-Gonzalez, Daniel Race, Nicholas S. Voets, Natalie L. Jenkins, Damian R. Sotiropoulos, Stamatios N. Acosta, Glen Cruz-Haces, Marcela Tang, Jonathan Shi, Riyi Jérusalem, Antoine Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title | Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title_full | Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title_fullStr | Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title_full_unstemmed | Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title_short | Cognition based bTBI mechanistic criteria; a tool for preventive and therapeutic innovations |
| title_sort | cognition based btbi mechanistic criteria; a tool for preventive and therapeutic innovations |
| url | https://eprints.nottingham.ac.uk/52610/ https://eprints.nottingham.ac.uk/52610/ https://eprints.nottingham.ac.uk/52610/ |