Synthesis of nucleoside-boronic esters hydrophobic pro-drugs: a possible route to improve hydrophilic nucleoside drug loading into polymer nanoparticles

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Synthesis of nucleoside-boronic esters hydrophobic pro-drugs: a possible route to improve hydrophilic nucleoside drug loading into polymer nanoparticles

Nucleoside analogues are active therapeutic agents for different types of diseases e.g. Cancer and virus infections. However, they are associated with several side effects due to off-target accumulation. Particulate delivery systems such as nanoparticles (NP) may be able to selectively target drug i...

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Bibliographic Details
Main Authors:	Abo-zeid, Yasmin, Mantovani, Giuseppe, Irving, William L., Garnett, Martin.C
Format:	Article
Published:	Elsevier 2018
Subjects:	Polymer nanoparticles; Poly (glycerol adipate); acylated Poly (glycerol adipate); phenyl boronic acid compounds; hydrophilic nucleoside
Online Access:	https://eprints.nottingham.ac.uk/52548/

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