Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers
Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a range of (meth)acrylate copolymers which contain monomers reported to deliver bacte...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
American Chemical Society
2016
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| Online Access: | https://eprints.nottingham.ac.uk/52535/ |
| _version_ | 1848798747812691968 |
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| author | Adlington, Kevin Nguyen, Nam T. Eaves, Elizabeth Yang, Jing Chang, Chien-Yi Li, Jianing Gower, Alexandra L. Stimpson, Amy Anderson, Daniel G. Langer, Robert Davies, Martyn C. Hook, Andrew L. Williams, Paul Alexander, Morgan R. Irvine, Derek J. |
| author_facet | Adlington, Kevin Nguyen, Nam T. Eaves, Elizabeth Yang, Jing Chang, Chien-Yi Li, Jianing Gower, Alexandra L. Stimpson, Amy Anderson, Daniel G. Langer, Robert Davies, Martyn C. Hook, Andrew L. Williams, Paul Alexander, Morgan R. Irvine, Derek J. |
| author_sort | Adlington, Kevin |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a range of (meth)acrylate copolymers which contain monomers reported to deliver bacterial resistance to surfaces. This optimization allows such monomers to be employed within novel coatings to reduce bacterial attachment to silicone urinary catheters. We show that the flexibility of copolymers can be tuned to match that of the silicone catheter substrate, by copolymerizing these polymers with a lower Tg monomer such that it passes the flexing fatigue tests as coatings upon catheters, that the homopolymers failed. Furthermore, the Tg values of the copolymers are shown to be readily estimated by the Fox equation. The bacterial resistance performance of these copolymers were typically found to be better than the neat silicone or a commercial silver containing hydrogel surface, when the monomer feed contained only 25 v% of the “hit” monomer. The method of initiation (either photo or thermal) was shown not to affect the bacterial resistance of the copolymers. Optimized synthesis conditions to ensure that the correct copolymer composition and to prevent the onset of gelation are detailed. |
| first_indexed | 2025-11-14T20:24:41Z |
| format | Article |
| id | nottingham-52535 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:24:41Z |
| publishDate | 2016 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-525352020-05-04T17:59:31Z https://eprints.nottingham.ac.uk/52535/ Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers Adlington, Kevin Nguyen, Nam T. Eaves, Elizabeth Yang, Jing Chang, Chien-Yi Li, Jianing Gower, Alexandra L. Stimpson, Amy Anderson, Daniel G. Langer, Robert Davies, Martyn C. Hook, Andrew L. Williams, Paul Alexander, Morgan R. Irvine, Derek J. Developing medical devices that resist bacterial attachment and subsequent biofilm formation is highly desirable. In this paper, we report the optimization of the molecular structure and thus material properties of a range of (meth)acrylate copolymers which contain monomers reported to deliver bacterial resistance to surfaces. This optimization allows such monomers to be employed within novel coatings to reduce bacterial attachment to silicone urinary catheters. We show that the flexibility of copolymers can be tuned to match that of the silicone catheter substrate, by copolymerizing these polymers with a lower Tg monomer such that it passes the flexing fatigue tests as coatings upon catheters, that the homopolymers failed. Furthermore, the Tg values of the copolymers are shown to be readily estimated by the Fox equation. The bacterial resistance performance of these copolymers were typically found to be better than the neat silicone or a commercial silver containing hydrogel surface, when the monomer feed contained only 25 v% of the “hit” monomer. The method of initiation (either photo or thermal) was shown not to affect the bacterial resistance of the copolymers. Optimized synthesis conditions to ensure that the correct copolymer composition and to prevent the onset of gelation are detailed. American Chemical Society 2016-07-26 Article PeerReviewed Adlington, Kevin, Nguyen, Nam T., Eaves, Elizabeth, Yang, Jing, Chang, Chien-Yi, Li, Jianing, Gower, Alexandra L., Stimpson, Amy, Anderson, Daniel G., Langer, Robert, Davies, Martyn C., Hook, Andrew L., Williams, Paul, Alexander, Morgan R. and Irvine, Derek J. (2016) Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers. Biomacromolecules, 17 (9). pp. 2830-2838. ISSN 1526-4602 https://pubs.acs.org/doi/10.1021/acs.biomac.6b00615 doi:10.1021/acs.biomac.6b00615 doi:10.1021/acs.biomac.6b00615 |
| spellingShingle | Adlington, Kevin Nguyen, Nam T. Eaves, Elizabeth Yang, Jing Chang, Chien-Yi Li, Jianing Gower, Alexandra L. Stimpson, Amy Anderson, Daniel G. Langer, Robert Davies, Martyn C. Hook, Andrew L. Williams, Paul Alexander, Morgan R. Irvine, Derek J. Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title | Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title_full | Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title_fullStr | Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title_full_unstemmed | Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title_short | Application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| title_sort | application of targeted molecular and material property optimization to bacterial attachment-resistant (meth)acrylate polymers |
| url | https://eprints.nottingham.ac.uk/52535/ https://eprints.nottingham.ac.uk/52535/ https://eprints.nottingham.ac.uk/52535/ |