Synthesis and properties of a biodegradable polymer-drug conjugate: Methotrexate-poly(glycerol adipate)

QR Code

Synthesis and properties of a biodegradable polymer-drug conjugate: Methotrexate-poly(glycerol adipate)

Polymer-drug conjugates have been actively developed as potential anticancer drug delivery systems. In this study, we report the first polymer-anticancer drug conjugate with poly(glycerol adipate) (PGA) through the successful conjugation of methotrexate (MTX). MTX-PGA conjugates were controllably an...

Full description

Bibliographic Details
Main Authors:	Suksiriworapong, Jiraphong, Taresco, Vincenzo, Ivanov, Delyan P., Styliari, Ioanna D., Sakchaisri, Krisada, Junyaprasert, Varaporn Buraphacheep, Garnett, Martin C.
Format:	Article
Published:	Elsevier 2018
Subjects:	Poly(glycerol adipate); Methotrexate; Polymer-drug conjugate; Nanoparticle; Osteosarcoma cell
Online Access:	https://eprints.nottingham.ac.uk/52336/

Similar Items

Variation in structure and properties of poly(glycerol adipate) via control of chain branching during enzymatic synthesis
by: Taresco, Vincenzo, et al.
Published: (2016)

Properties of acyl modified poly(glycerol-adipate) comb-like polymers and their self-assembly into nanoparticles
by: Taresco, Vincenzo, et al.
Published: (2016)

Synthesis of nucleoside-boronic esters hydrophobic pro-drugs: a possible route to improve hydrophilic nucleoside drug loading into polymer nanoparticles
by: Abo-zeid, Yasmin, et al.
Published: (2018)

Multiscale modelling of drug-polymer nanoparticle assembly identifies parameters influencing drug encapsulation efficiency
by: Mackenzie, Robert, et al.
Published: (2015)

Computational modelling of polymer-based drug delivery systems
by: Mackenzie, R.C.
Published: (2015)

Enhanced nanoparticle uptake into virus infected cells: could nanoparticles be useful in antiviral therapy?
by: Abo-zeid, Yasmin, et al.
Published: (2018)

OPTIMIZATION OF NOVEL POLYMERIC NANOPARTICLE FORMULATIONS FOR INHALED TARGETED THERAPY OF LUNG DISEASES
by: Elbahr, Ramy Said Hussenien Mohamed
Published: (2024)

Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort
by: McWilliams, Daniel F., et al.
Published: (2013)

Single droplet microrheology
by: Harrold, Victoria C.
Published: (2021)

Mechanism of anti-cancer activity of (z)-3-hydroxy-1-(2-hydroxyphenyl)-3-phenylprop–2–en-1-one (DK1) in human osteosarcoma cells and subchronic toxicity evaluation in BALB/C mice
by: Aziz, Muhammad Nazirul Mubin
Published: (2021)

The complete solution to the Sylvester-polynomial-conjugate matrix equations
by: Wu, A., et al.
Published: (2011)

Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics
by: Simpson, Siobhan, et al.
Published: (2017)

Conjugate gradient methods with sufficient descent condition for large-scale unconstrained optimization
by: Ling, Mei Mei
Published: (2015)

An Evolutionary Variable Neighborhood Search for Selecting Combinational Gene Signatures in Predicting Chemo-Response of Osteosarcoma
by: Chan, Kit Yan, et al.
Published: (2010)

Glycerol as alternative substrate for bioethanol production using free and immobilized Escherichia coli SS1
by: Adnan, Nur Amelia Azreen
Published: (2014)

Synthesis of heparin conjugated silica nanoparticles for nanomedicine applications
by: Jaradat, Abdolelah
Published: (2020)

Novel organoalanes in organic synthesis and mechanistic insight in conjugate addition
by: Willcox, Darren
Published: (2014)

Scaled three-term conjugate gradient method via Davidon-Fletcher-Powell update for unconstrained optimization
by: Ibrahim, Arzuka
Published: (2015)

Effect of major impurities in crude glycerol on solubility and properties of glycerol/methanol/bio-oil blends
by: Zhang, Mingming, et al.
Published: (2015)

A remarkable activity of glycerol electrooxidation on gold in alkaline medium
by: Zhang, J., et al.
Published: (2012)

Pengubahsuaian ke Atas Kaedah Kecerunan Konjugat untuk Peminimuman Tak Berkekangan
by: Bachok @ Lati, Norfifah
Published: (2003)

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications
by: Taresco, Vincenzo, et al.
Published: (2016)

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications
by: Taresco, Vincenzo, et al.
Published: (2016)

Tying the CNOT: CNOT1 regulates poly(A) tail length at the end and the beginning
by: Williams, Kathryn
Published: (2021)

Effect of halloysite nanoclay concentration and addition of glycerol on mechanical properties of bionanocomposite films
by: Risyon, Nazratul Putri, et al.
Published: (2016)

On conjugate product of complex polynomials
by: Wu, A., et al.
Published: (2011)

Biosynthesis of Poly (3-Hydroxybutyrate-Co-3-Hydroyvalerate) Copolymer from Organic Acids Using Comamonas sp. EB172
by: Zakaria @ Mamat, Mohd Rafein
Published: (2011)

Kinetic studies of copper-catalysed conjugate addition reactions with organoaluminium reagents and their implementation towards enantioselective synthesis of quinolone derivatives
by: Kingsbury, A.
Published: (2019)

A simple lattice Boltzmann model for conjugate heat transfer research
by: Chen, S., et al.
Published: (2017)

Simulation of conjugate heat transfer between fluid-saturated porous media and solid wall
by: Chen, Sheng
Published: (2018)

Dually sensitive dextran-based micelles for methotrexate delivery
by: Blanco-Fernandez, B., et al.
Published: (2017)

Iterative solutions to the Kalman-Yakubovich-conjugate matrix equation
by: Wu, A., et al.
Published: (2011)

Modulating oxytocin brain penetration via intranasal delivery and a novel conjugate peptide (OT-GET)
by: Wong, Sara Wei Ting
Published: (2022)

Using equilibrium thermodynamics in the study of metasomatic alteration, illustrated by an application to serpentinites
by: Evans, Katy, et al.
Published: (2013)

Multiple Alternate Steps Gradient Methods For Unconstrained Optimization
by: Lee, Sui Fong
Published: (2009)

Modified quasi-Newton type methods using gradient flow system for solving unconstrained optimization
by: Yap, Chui Ying
Published: (2016)

Preparation and characterization of poly(hydroxybutyrate-co-hydroxyvalerate)/clay nanocomposites
by: Mohd Anuar, Mohd Firdaus
Published: (2012)

Non-halogenated recovery method of intracellular polyhydroxyalkanoates from local isolate Comamonas sp. EB172
by: Mohammadi, Mitra
Published: (2012)

Mechanism of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) depolymerization in superheated steam and characterization of the degradation products for biomaterial applications
by: Rajaratanam, Dhurga Devi
Published: (2017)

Suppression of expulsion of Aspiculuris tetraptera in hydrocortisone and methotrexate treated mice
by: Behnke, Jerzy M.
Published: (1975)