Relationships between neuronal oscillatory amplitude and dynamic functional connectivity
Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in particular, whether such fluctuations reflect local dy...
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| Format: | Article |
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Oxford Journals
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52313/ |
| _version_ | 1848798697248260096 |
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| author | Tewarie, Prejaas K. Hunt, Benjamin A. E. O'Neill, George C. Byrne, Aine Aquino, Kevin Bauer, Markus Mullinger, Karen J. Coombes, Stephen Brookes, Matthew J. |
| author_facet | Tewarie, Prejaas K. Hunt, Benjamin A. E. O'Neill, George C. Byrne, Aine Aquino, Kevin Bauer, Markus Mullinger, Karen J. Coombes, Stephen Brookes, Matthew J. |
| author_sort | Tewarie, Prejaas K. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in particular, whether such fluctuations reflect local dynamics, integration between regions, or both, is unknown. Here, using magnetoencephalography (MEG), we show that movement induced oscillatory modulation is associated with transient connectivity between sensorimotor regions. Further, in resting state data, we demonstrate a significant association between oscillatory modulation and dynamic connectivity. A confound with such empirical measurements is that increased amplitude necessarily means increased signal to noise ratio (SNR): this means that the question of whether amplitude and connectivity are genuinely coupled, or whether increased connectivity is observed purely due to increased SNR is unanswered. Here we counter this problem by analogy with computational models which show that, in the presence of global network coupling and local multistability, the link between oscillatory modulation and long range connectivity is a natural consequence of neural networks. Our results provide evidence for the notion that connectivity is mediated by neural oscillations, and suggest that time-frequency spectrograms are not merely a description of local synchrony but also reflect fluctuations in long range connectivity. |
| first_indexed | 2025-11-14T20:23:53Z |
| format | Article |
| id | nottingham-52313 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:23:53Z |
| publishDate | 2018 |
| publisher | Oxford Journals |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-523132020-05-04T19:40:39Z https://eprints.nottingham.ac.uk/52313/ Relationships between neuronal oscillatory amplitude and dynamic functional connectivity Tewarie, Prejaas K. Hunt, Benjamin A. E. O'Neill, George C. Byrne, Aine Aquino, Kevin Bauer, Markus Mullinger, Karen J. Coombes, Stephen Brookes, Matthew J. Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in particular, whether such fluctuations reflect local dynamics, integration between regions, or both, is unknown. Here, using magnetoencephalography (MEG), we show that movement induced oscillatory modulation is associated with transient connectivity between sensorimotor regions. Further, in resting state data, we demonstrate a significant association between oscillatory modulation and dynamic connectivity. A confound with such empirical measurements is that increased amplitude necessarily means increased signal to noise ratio (SNR): this means that the question of whether amplitude and connectivity are genuinely coupled, or whether increased connectivity is observed purely due to increased SNR is unanswered. Here we counter this problem by analogy with computational models which show that, in the presence of global network coupling and local multistability, the link between oscillatory modulation and long range connectivity is a natural consequence of neural networks. Our results provide evidence for the notion that connectivity is mediated by neural oscillations, and suggest that time-frequency spectrograms are not merely a description of local synchrony but also reflect fluctuations in long range connectivity. Oxford Journals 2018-05-16 Article PeerReviewed Tewarie, Prejaas K., Hunt, Benjamin A. E., O'Neill, George C., Byrne, Aine, Aquino, Kevin, Bauer, Markus, Mullinger, Karen J., Coombes, Stephen and Brookes, Matthew J. (2018) Relationships between neuronal oscillatory amplitude and dynamic functional connectivity. Cerebral Cortex, 29 (6). pp. 2668-2681. ISSN 1460-2199 Dynamic functional connectivity; Amplitude envelopes; Magnetoencephalography; Coupled neural masses; Neural mass bifurcation; Neuronal oscillations; Time-frequency https://academic.oup.com/cercor/article/29/6/2668/5036075 doi:10.1093/cercor/bhy136 doi:10.1093/cercor/bhy136 |
| spellingShingle | Dynamic functional connectivity; Amplitude envelopes; Magnetoencephalography; Coupled neural masses; Neural mass bifurcation; Neuronal oscillations; Time-frequency Tewarie, Prejaas K. Hunt, Benjamin A. E. O'Neill, George C. Byrne, Aine Aquino, Kevin Bauer, Markus Mullinger, Karen J. Coombes, Stephen Brookes, Matthew J. Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title | Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title_full | Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title_fullStr | Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title_full_unstemmed | Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title_short | Relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| title_sort | relationships between neuronal oscillatory amplitude and dynamic functional connectivity |
| topic | Dynamic functional connectivity; Amplitude envelopes; Magnetoencephalography; Coupled neural masses; Neural mass bifurcation; Neuronal oscillations; Time-frequency |
| url | https://eprints.nottingham.ac.uk/52313/ https://eprints.nottingham.ac.uk/52313/ https://eprints.nottingham.ac.uk/52313/ |