Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging
Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constipation treatment, in patients and controls. Met...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52285/ |
| _version_ | 1848798690644328448 |
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| author | Major, Giles Murray, Kathryn Singh, Gulzar Nowak, Adam Hoad, Caroline L. Marciani, Luca Silos-Santiago, ada Kurtz, Caroline B. Johnston, Jeffrey Gowland, Penny Spiller, Robin C. |
| author_facet | Major, Giles Murray, Kathryn Singh, Gulzar Nowak, Adam Hoad, Caroline L. Marciani, Luca Silos-Santiago, ada Kurtz, Caroline B. Johnston, Jeffrey Gowland, Penny Spiller, Robin C. |
| author_sort | Major, Giles |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constipation treatment, in patients and controls.
Methods: Two crossover studies: 1) adults without constipation (controls, n=9) took three treatments in randomised order for 6 days - maltodextrin (placebo), psyllium 3.5g t.d.s and 7g t.d.s.; 2) adults with chronic constipation (patients, n=20) took placebo and psyllium 7g t.d.s. for 6 days. MRI was performed fasting and postprandially on day 6. Measurements included small bowel and ascending colon water content, colonic volume, transit time and MR relaxometry (T1, T2) to assess colonic chyme. Stool water percentage was measured.
Results: 7g psyllium t.d.s. increased fasting colonic volumes in controls from median 372mL (IQR 284-601) to 578 mL (IQR 510-882), and in patients from median 831mL (IQR 745–934) to 1104mL (847–1316), P<0.05). Mean postprandial small bowel water was higher in controls and patients after 7g psyllium t.d.s. vs. placebo. Whole gut transit was slower in patients than controls (P <0.05). T1 of the descending colon chyme (fasting) was lower in patients [213ms, 176–420] than controls [440ms, 352–884, P <0.05] on placebo, but increased by 7 g psyllium t.d.s. [590ms, 446–1338), P<0.001]. Descending colon T1 correlated with baseline stool water content and stool frequency on treatment.
Conclusions and Inferences: MRI measurements can objectively demonstrate the mode of action of therapy targeting intestinal fluid content in constipation. |
| first_indexed | 2025-11-14T20:23:47Z |
| format | Article |
| id | nottingham-52285 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:23:47Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-522852024-08-15T15:29:10Z https://eprints.nottingham.ac.uk/52285/ Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging Major, Giles Murray, Kathryn Singh, Gulzar Nowak, Adam Hoad, Caroline L. Marciani, Luca Silos-Santiago, ada Kurtz, Caroline B. Johnston, Jeffrey Gowland, Penny Spiller, Robin C. Background: In functional gastrointestinal disorders a lack of objective biomarkers limits evaluation of underlying mechanisms. We aimed to demonstrate the utility of Magnetic Resonance Imaging (MRI) for this task using psyllium, an effective constipation treatment, in patients and controls. Methods: Two crossover studies: 1) adults without constipation (controls, n=9) took three treatments in randomised order for 6 days - maltodextrin (placebo), psyllium 3.5g t.d.s and 7g t.d.s.; 2) adults with chronic constipation (patients, n=20) took placebo and psyllium 7g t.d.s. for 6 days. MRI was performed fasting and postprandially on day 6. Measurements included small bowel and ascending colon water content, colonic volume, transit time and MR relaxometry (T1, T2) to assess colonic chyme. Stool water percentage was measured. Results: 7g psyllium t.d.s. increased fasting colonic volumes in controls from median 372mL (IQR 284-601) to 578 mL (IQR 510-882), and in patients from median 831mL (IQR 745–934) to 1104mL (847–1316), P<0.05). Mean postprandial small bowel water was higher in controls and patients after 7g psyllium t.d.s. vs. placebo. Whole gut transit was slower in patients than controls (P <0.05). T1 of the descending colon chyme (fasting) was lower in patients [213ms, 176–420] than controls [440ms, 352–884, P <0.05] on placebo, but increased by 7 g psyllium t.d.s. [590ms, 446–1338), P<0.001]. Descending colon T1 correlated with baseline stool water content and stool frequency on treatment. Conclusions and Inferences: MRI measurements can objectively demonstrate the mode of action of therapy targeting intestinal fluid content in constipation. Wiley 2018-05-28 Article PeerReviewed Major, Giles, Murray, Kathryn, Singh, Gulzar, Nowak, Adam, Hoad, Caroline L., Marciani, Luca, Silos-Santiago, ada, Kurtz, Caroline B., Johnston, Jeffrey, Gowland, Penny and Spiller, Robin C. (2018) Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging. Neurogastroenterology and Motility . ISSN 1365-2982 (In Press) ispaghula laxative relaxometry MRI |
| spellingShingle | ispaghula laxative relaxometry MRI Major, Giles Murray, Kathryn Singh, Gulzar Nowak, Adam Hoad, Caroline L. Marciani, Luca Silos-Santiago, ada Kurtz, Caroline B. Johnston, Jeffrey Gowland, Penny Spiller, Robin C. Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title | Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title_full | Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title_fullStr | Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title_full_unstemmed | Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title_short | Demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| title_sort | demonstration of differences in colonic volumes, transit, chyme consistency and response to psyllium between healthy and constipated subjects using magnetic resonance imaging |
| topic | ispaghula laxative relaxometry MRI |
| url | https://eprints.nottingham.ac.uk/52285/ |