Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis
OBJECTIVE: To perform a systematic review and meta-analysis of the association between alcohol consumption and tuberculosis risk. METHODS: Medline, EMBASE and Web of Science were searched for observational studies from 2005 to April 2018. Reference lists of included studies were screened. RESULTS:...
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| Format: | Article |
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International Union Against Tuberculosis and Lung Disease
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52282/ |
| _version_ | 1848798690068660224 |
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| author | Simou, Evangelia Britton, John Leonardi-Bee, Jo |
| author_facet | Simou, Evangelia Britton, John Leonardi-Bee, Jo |
| author_sort | Simou, Evangelia |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | OBJECTIVE: To perform a systematic review and meta-analysis of the association between alcohol consumption and tuberculosis risk.
METHODS: Medline, EMBASE and Web of Science were searched for observational studies from 2005 to April 2018. Reference lists of included studies were screened.
RESULTS: Forty nine studies were included. Compared to people with low or no alcohol intake, the risk of tuberculosis in people with high or any alcohol consumption was increased by a relative odds of 1.90 (95% CI: 1.-2.23). Substantial levels of heterogeneity were seen (I2=82%), but there was no evidence of publication bias (P=0.). Sensitivity analysis restricted to studies using no alcohol drinking as a reference group found a slightly lower but still increased risk (Odds Ratio= 1.59, 95%CI: 1.38-1.84). Subgroup analyses found no significant differences in relation to study design and quality, geographic location, publication year, and adjustment for confounders. A pooled analysis of a further four studies reporting hazard ratios, found nearly a tripling increase in risk of TB in relation to alcohol consumption during follow-up (HR=2.81, 95%CI: 2.12-3.74). An exposure-response analysis showed that for every 10-20 grams daily alcohol intake, there was 12% increase in TB risk.
CONCLUSION: Alcohol consumption is an important risk factor for the development of TB. |
| first_indexed | 2025-11-14T20:23:46Z |
| format | Article |
| id | nottingham-52282 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:23:46Z |
| publishDate | 2018 |
| publisher | International Union Against Tuberculosis and Lung Disease |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-522822020-05-04T19:39:33Z https://eprints.nottingham.ac.uk/52282/ Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis Simou, Evangelia Britton, John Leonardi-Bee, Jo OBJECTIVE: To perform a systematic review and meta-analysis of the association between alcohol consumption and tuberculosis risk. METHODS: Medline, EMBASE and Web of Science were searched for observational studies from 2005 to April 2018. Reference lists of included studies were screened. RESULTS: Forty nine studies were included. Compared to people with low or no alcohol intake, the risk of tuberculosis in people with high or any alcohol consumption was increased by a relative odds of 1.90 (95% CI: 1.-2.23). Substantial levels of heterogeneity were seen (I2=82%), but there was no evidence of publication bias (P=0.). Sensitivity analysis restricted to studies using no alcohol drinking as a reference group found a slightly lower but still increased risk (Odds Ratio= 1.59, 95%CI: 1.38-1.84). Subgroup analyses found no significant differences in relation to study design and quality, geographic location, publication year, and adjustment for confounders. A pooled analysis of a further four studies reporting hazard ratios, found nearly a tripling increase in risk of TB in relation to alcohol consumption during follow-up (HR=2.81, 95%CI: 2.12-3.74). An exposure-response analysis showed that for every 10-20 grams daily alcohol intake, there was 12% increase in TB risk. CONCLUSION: Alcohol consumption is an important risk factor for the development of TB. International Union Against Tuberculosis and Lung Disease 2018-06-05 Article PeerReviewed Simou, Evangelia, Britton, John and Leonardi-Bee, Jo (2018) Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis. International Journal of Tuberculosis and Lung Disease . ISSN 1815-7920 (In Press) alcohol; tuberculosis; meta-analysis |
| spellingShingle | alcohol; tuberculosis; meta-analysis Simou, Evangelia Britton, John Leonardi-Bee, Jo Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title | Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title_full | Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title_fullStr | Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title_full_unstemmed | Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title_short | Alcohol consumption and the risk of tuberculosis: a systematic review and Meta-analysis |
| title_sort | alcohol consumption and the risk of tuberculosis: a systematic review and meta-analysis |
| topic | alcohol; tuberculosis; meta-analysis |
| url | https://eprints.nottingham.ac.uk/52282/ |