Characterisation of anticancer properties of a novel and naturally isolated bisindole alkaloid, conofolidine

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Characterisation of anticancer properties of a novel and naturally isolated bisindole alkaloid, conofolidine

Natural products play a pivotal role in the exploration of new cancer therapies of which the plant kingdom is a substantial source. Conofolidine is a novel bisindole alkaloid isolated from Malayan plant Tabernaemontana Corymbosa and belongs to the family of the known vinca alkaloid conophylline. To...

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Bibliographic Details
Main Author:	Al-Hayali, Mohammed Zuhair Khaleel
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Subjects:	conofolidine conophylline bisindole alkaloid Tabernaemontana Corymbosa anticancer carcinoma cells apoptosis senescence ROS generation DNA damage G1/S arrest CDK2 cyclin A2 c-Myc p53 (R273H) p21 MCM4 Akt ERK STAT.
Online Access:	https://eprints.nottingham.ac.uk/52200/

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