Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment
Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investigate both stationary (i.e. time averaged) and rapid...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52146/ |
| _version_ | 1848798658548465664 |
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| author | Brookes, Matthew J. Groom, Madeleine J. Liuzzi, Lucrezia Hill, Ryan M. Smith, Helen J.F. Briley, Paul M. Hall, Emma L. Hunt, Benjamin A.E. Gascoyne, Lauren E. Taylor, Margot J. Liddle, Peter F. Morris, Peter G. Woolrich, Mark W. Liddle, Elizabeth B. |
| author_facet | Brookes, Matthew J. Groom, Madeleine J. Liuzzi, Lucrezia Hill, Ryan M. Smith, Helen J.F. Briley, Paul M. Hall, Emma L. Hunt, Benjamin A.E. Gascoyne, Lauren E. Taylor, Margot J. Liddle, Peter F. Morris, Peter G. Woolrich, Mark W. Liddle, Elizabeth B. |
| author_sort | Brookes, Matthew J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investigate both stationary (i.e. time averaged) and rapidly modulating (dynamic) electrophysiological connectivity, in participants aged from mid-childhood to early adulthood (youngest participant 9 years old; oldest participant 25 years old). Stationary functional connectivity (measured via inter-regional coordination of neural oscillations) increased with age in the alpha and beta frequency bands, particularly in bilateral parietal and temporo-parietal connections. Our dynamic analysis (also applied to alpha/beta oscillations) revealed the spatiotemporal signatures of 8 dynamic networks; these modulate on a ∼100 ms time scale, and temporal stability in attentional networks was found to increase with age. Significant overlap was found between age-modulated dynamic networks and inter-regional oscillatory coordination, implying that altered network dynamics underlie age related changes in functional connectivity. Our results provide novel insights into brain network electrophysiology, and lay a foundation for future work in childhood disorders. |
| first_indexed | 2025-11-14T20:23:16Z |
| format | Article |
| id | nottingham-52146 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:23:16Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-521462020-05-04T19:43:20Z https://eprints.nottingham.ac.uk/52146/ Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment Brookes, Matthew J. Groom, Madeleine J. Liuzzi, Lucrezia Hill, Ryan M. Smith, Helen J.F. Briley, Paul M. Hall, Emma L. Hunt, Benjamin A.E. Gascoyne, Lauren E. Taylor, Margot J. Liddle, Peter F. Morris, Peter G. Woolrich, Mark W. Liddle, Elizabeth B. Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investigate both stationary (i.e. time averaged) and rapidly modulating (dynamic) electrophysiological connectivity, in participants aged from mid-childhood to early adulthood (youngest participant 9 years old; oldest participant 25 years old). Stationary functional connectivity (measured via inter-regional coordination of neural oscillations) increased with age in the alpha and beta frequency bands, particularly in bilateral parietal and temporo-parietal connections. Our dynamic analysis (also applied to alpha/beta oscillations) revealed the spatiotemporal signatures of 8 dynamic networks; these modulate on a ∼100 ms time scale, and temporal stability in attentional networks was found to increase with age. Significant overlap was found between age-modulated dynamic networks and inter-regional oscillatory coordination, implying that altered network dynamics underlie age related changes in functional connectivity. Our results provide novel insights into brain network electrophysiology, and lay a foundation for future work in childhood disorders. Elsevier 2018-07-01 Article PeerReviewed Brookes, Matthew J., Groom, Madeleine J., Liuzzi, Lucrezia, Hill, Ryan M., Smith, Helen J.F., Briley, Paul M., Hall, Emma L., Hunt, Benjamin A.E., Gascoyne, Lauren E., Taylor, Margot J., Liddle, Peter F., Morris, Peter G., Woolrich, Mark W. and Liddle, Elizabeth B. (2018) Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment. NeuroImage, 174 . pp. 563-575. ISSN 1053-8119 https://www.sciencedirect.com/science/article/pii/S1053811918301939?via%3Dihub doi:10.1016/j.neuroimage.2018.03.008 doi:10.1016/j.neuroimage.2018.03.008 |
| spellingShingle | Brookes, Matthew J. Groom, Madeleine J. Liuzzi, Lucrezia Hill, Ryan M. Smith, Helen J.F. Briley, Paul M. Hall, Emma L. Hunt, Benjamin A.E. Gascoyne, Lauren E. Taylor, Margot J. Liddle, Peter F. Morris, Peter G. Woolrich, Mark W. Liddle, Elizabeth B. Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title | Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title_full | Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title_fullStr | Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title_full_unstemmed | Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title_short | Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| title_sort | altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment |
| url | https://eprints.nottingham.ac.uk/52146/ https://eprints.nottingham.ac.uk/52146/ https://eprints.nottingham.ac.uk/52146/ |