Risk profiles for heavy drinking in adolescence: differential effects of gender
Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear wheth...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Wiley
2018
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| Online Access: | https://eprints.nottingham.ac.uk/52133/ |
| _version_ | 1848798655213993984 |
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| author | Seo, Sambu Beck, Anne Matthis, Caroline Genauck, Alexander Banaschewski, Tobias Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Flor, Herta Frouin, Vincent Garavan, Hugh Gowland, Penny Ittermann, Bernd Martinot, Jean-Luc Paillère Martinot, Marie-Laure Nees, Frauke Papadopoulos Orfanos, Dimitri Poustka, Luise Hohmann, Sarah Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Desrivières, Sylvane Heinz, Andreas Schumann, Gunter Obermayer, Klaus |
| author_facet | Seo, Sambu Beck, Anne Matthis, Caroline Genauck, Alexander Banaschewski, Tobias Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Flor, Herta Frouin, Vincent Garavan, Hugh Gowland, Penny Ittermann, Bernd Martinot, Jean-Luc Paillère Martinot, Marie-Laure Nees, Frauke Papadopoulos Orfanos, Dimitri Poustka, Luise Hohmann, Sarah Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Desrivières, Sylvane Heinz, Andreas Schumann, Gunter Obermayer, Klaus |
| author_sort | Seo, Sambu |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross‐sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19—for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19‐year‐olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress assessment in adolescents may help to better target counseling and prevention programs. This might reduce heavy drinking in adolescents and hence reduce the risk of early brain atrophy, especially in females. In turn, this could additionally reduce the risk of developing alcohol use disorders later in adulthood. |
| first_indexed | 2025-11-14T20:23:13Z |
| format | Article |
| id | nottingham-52133 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:23:13Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-521332020-05-04T19:38:15Z https://eprints.nottingham.ac.uk/52133/ Risk profiles for heavy drinking in adolescence: differential effects of gender Seo, Sambu Beck, Anne Matthis, Caroline Genauck, Alexander Banaschewski, Tobias Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Flor, Herta Frouin, Vincent Garavan, Hugh Gowland, Penny Ittermann, Bernd Martinot, Jean-Luc Paillère Martinot, Marie-Laure Nees, Frauke Papadopoulos Orfanos, Dimitri Poustka, Luise Hohmann, Sarah Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Desrivières, Sylvane Heinz, Andreas Schumann, Gunter Obermayer, Klaus Abnormalities across different domains of neuropsychological functioning may constitute a risk factor for heavy drinking during adolescence and for developing alcohol use disorders later in life. However, the exact nature of such multi‐domain risk profiles is unclear, and it is further unclear whether these risk profiles differ between genders. We combined longitudinal and cross‐sectional analyses on the large IMAGEN sample (N ≈ 1000) to predict heavy drinking at age 19 from gray matter volume as well as from psychosocial data at age 14 and 19—for males and females separately. Heavy drinking was associated with reduced gray matter volume in 19‐year‐olds' bilateral ACC, MPFC, thalamus, middle, medial and superior OFC as well as left amygdala and anterior insula and right inferior OFC. Notably, this lower gray matter volume associated with heavy drinking was stronger in females than in males. In both genders, we observed that impulsivity and facets of novelty seeking at the age of 14 and 19, as well as hopelessness at the age of 14, are risk factors for heavy drinking at the age of 19. Stressful life events with internal (but not external) locus of control were associated with heavy drinking only at age 19. Personality and stress assessment in adolescents may help to better target counseling and prevention programs. This might reduce heavy drinking in adolescents and hence reduce the risk of early brain atrophy, especially in females. In turn, this could additionally reduce the risk of developing alcohol use disorders later in adulthood. Wiley 2018-05-30 Article PeerReviewed Seo, Sambu, Beck, Anne, Matthis, Caroline, Genauck, Alexander, Banaschewski, Tobias, Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Quinlan, Erin Burke, Flor, Herta, Frouin, Vincent, Garavan, Hugh, Gowland, Penny, Ittermann, Bernd, Martinot, Jean-Luc, Paillère Martinot, Marie-Laure, Nees, Frauke, Papadopoulos Orfanos, Dimitri, Poustka, Luise, Hohmann, Sarah, Fröhner, Juliane H., Smolka, Michael N., Walter, Henrik, Whelan, Robert, Desrivières, Sylvane, Heinz, Andreas, Schumann, Gunter and Obermayer, Klaus (2018) Risk profiles for heavy drinking in adolescence: differential effects of gender. Addiction Biology . ISSN 1355-6215 https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12636 doi:10.1111/adb.12636 doi:10.1111/adb.12636 |
| spellingShingle | Seo, Sambu Beck, Anne Matthis, Caroline Genauck, Alexander Banaschewski, Tobias Bokde, Arun L.W. Bromberg, Uli Büchel, Christian Quinlan, Erin Burke Flor, Herta Frouin, Vincent Garavan, Hugh Gowland, Penny Ittermann, Bernd Martinot, Jean-Luc Paillère Martinot, Marie-Laure Nees, Frauke Papadopoulos Orfanos, Dimitri Poustka, Luise Hohmann, Sarah Fröhner, Juliane H. Smolka, Michael N. Walter, Henrik Whelan, Robert Desrivières, Sylvane Heinz, Andreas Schumann, Gunter Obermayer, Klaus Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title_full | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title_fullStr | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title_full_unstemmed | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title_short | Risk profiles for heavy drinking in adolescence: differential effects of gender |
| title_sort | risk profiles for heavy drinking in adolescence: differential effects of gender |
| url | https://eprints.nottingham.ac.uk/52133/ https://eprints.nottingham.ac.uk/52133/ https://eprints.nottingham.ac.uk/52133/ |