Targeting ataxia telangiectasia-mutated and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized cancer therapy

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Targeting ataxia telangiectasia-mutated and Rad3-related kinase (ATR) in PTEN-deficient breast cancers for personalized cancer therapy

Background: Phosphatase and tensin homolog (PTEN) is a multifunctional gene which acts as a tumour suppressor gene and is involved in DND damage response (DDR) mechanisms. PTEN has been found to be mutated in different types of human cancers including breast cancer. Ataxia-telangiectasia mutated...

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Bibliographic Details
Main Author:	Alsubhi, Nouf
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Subjects:	Phosphatase and tensin homolog; Breast cancer mutations; ATR inhibitor; Personalized cancer treatment; DNA damage; DNA repair
Online Access:	https://eprints.nottingham.ac.uk/52080/

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