Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

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Metabolic therapy with PEG-arginase induces a sustained complete remission in immunotherapy-resistant melanoma

Background Metastatic melanoma is an aggressive skin cancer with a poor prognosis. Current treatment strategies for high-stage melanoma are based around the use of immunotherapy with immune checkpoint inhibitors such as anti-PDL1 or anti-CTLA4 antibodies to stimulate anti-cancer T cell responses,...

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Bibliographic Details
Main Authors:	De Santo, Carmela, Cheng, Paul, Beggs, Andrew, Egan, Sharon, Bessudo, Albert, Mussai, Francis
Format:	Article
Published:	BioMed Central 2018
Subjects:	Arginase; Melanoma; Immunotherapy; Metabolism; BCT-100
Online Access:	https://eprints.nottingham.ac.uk/51989/

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