Gainfully employing descending controls in acute and chronic pain management
Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive information to the higher centres in the brain. Ir...
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| Format: | Article |
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Elsevier
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51987/ |
| _version_ | 1848798620269150208 |
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| author | White, Kate Targett, Mike Harris, John |
| author_facet | White, Kate Targett, Mike Harris, John |
| author_sort | White, Kate |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive information to the higher centres in the brain. Irrespective of the presence or absence of nociceptive inflow the activity of dorsal horn neurones is modulated by, amongst other things, local interneurones and descending midbrain and brainstem networks which can inhibit or facilitate dorsal horn transmission. These pathways therefore set the threshold for information inflow to the CNS. This review article summarises the anatomy, physiology and pharmacology particularly of these descending inhibitory and facilitatory pathways and explains why the study of descending modulation is essential if we are to develop more efficacious interventions for treating pain and relieving suffering. |
| first_indexed | 2025-11-14T20:22:40Z |
| format | Article |
| id | nottingham-51987 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:22:40Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-519872020-05-04T19:48:00Z https://eprints.nottingham.ac.uk/51987/ Gainfully employing descending controls in acute and chronic pain management White, Kate Targett, Mike Harris, John Specific primary afferent fibres termed nociceptors are responsible for transmitting nociceptive information. Centrally the axonal terminals of these fibres synapse with secondary projection neurones in the spinal dorsal horn to transmit nociceptive information to the higher centres in the brain. Irrespective of the presence or absence of nociceptive inflow the activity of dorsal horn neurones is modulated by, amongst other things, local interneurones and descending midbrain and brainstem networks which can inhibit or facilitate dorsal horn transmission. These pathways therefore set the threshold for information inflow to the CNS. This review article summarises the anatomy, physiology and pharmacology particularly of these descending inhibitory and facilitatory pathways and explains why the study of descending modulation is essential if we are to develop more efficacious interventions for treating pain and relieving suffering. Elsevier 2018-07-30 Article PeerReviewed White, Kate, Targett, Mike and Harris, John (2018) Gainfully employing descending controls in acute and chronic pain management. Veterinary Journal, 237 . pp. 16-1255. ISSN 1532-2971 Analgesia; DNIC; Nociception; Pain modulation https://www.sciencedirect.com/science/article/pii/S1090023318301801 doi:10.1016/j.tvjl.2018.05.005 doi:10.1016/j.tvjl.2018.05.005 |
| spellingShingle | Analgesia; DNIC; Nociception; Pain modulation White, Kate Targett, Mike Harris, John Gainfully employing descending controls in acute and chronic pain management |
| title | Gainfully employing descending controls in acute and chronic pain management |
| title_full | Gainfully employing descending controls in acute and chronic pain management |
| title_fullStr | Gainfully employing descending controls in acute and chronic pain management |
| title_full_unstemmed | Gainfully employing descending controls in acute and chronic pain management |
| title_short | Gainfully employing descending controls in acute and chronic pain management |
| title_sort | gainfully employing descending controls in acute and chronic pain management |
| topic | Analgesia; DNIC; Nociception; Pain modulation |
| url | https://eprints.nottingham.ac.uk/51987/ https://eprints.nottingham.ac.uk/51987/ https://eprints.nottingham.ac.uk/51987/ |