Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression
Objective: White matter microstructure alterations have recently been associated with adolescence depressive episodes, but it is unknown whether they predate depression. We investigated whether subthreshold-depression in adolescence is associated with white matter microstructure variations and wheth...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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American Psychiatric Publishing
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51953/ |
| _version_ | 1848798611983302656 |
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| author | Vulser, Hélène Martinot, Marie-Laure Paillère Artiges, Eric Miranda, Ruben Pentilla, Jani Grimmer, Yvonne van Noort, Betteke M. Stringaris, Argyris Struve, Maren Fadai, Tahmine Kappel, Viola Goodman, Robert Tzavara, Eleni Massaad, Charbel Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Brühl, Rüdiger Büchel, Christian Cattrell, Anna Conrod, Patricia Desrivieres, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomáš Proustka, Louise Rodehacke, Sarah Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Martinot, Jean-Luc Lemaitre, Hervé |
| author_facet | Vulser, Hélène Martinot, Marie-Laure Paillère Artiges, Eric Miranda, Ruben Pentilla, Jani Grimmer, Yvonne van Noort, Betteke M. Stringaris, Argyris Struve, Maren Fadai, Tahmine Kappel, Viola Goodman, Robert Tzavara, Eleni Massaad, Charbel Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Brühl, Rüdiger Büchel, Christian Cattrell, Anna Conrod, Patricia Desrivieres, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomáš Proustka, Louise Rodehacke, Sarah Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Martinot, Jean-Luc Lemaitre, Hervé |
| author_sort | Vulser, Hélène |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objective: White matter microstructure alterations have recently been associated with adolescence depressive episodes, but it is unknown whether they predate depression. We investigated whether subthreshold-depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome.
Method: Adolescents with subthreshold-depression (n=96) and healthy controls (n=336), drawn from a community-based cohort, were compared using diffusion tensor imaging and whole-brain tractbased spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followedup at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines from the TBSS analysis resulting regions, and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. We searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold-depression and depression at follow-up, and then explored the specificity of the findings.
Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold-depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between baseline subthreshold-depression and follow-up depression was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression.
Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex might denote higher risk of transition to depression in adolescents. |
| first_indexed | 2025-11-14T20:22:32Z |
| format | Article |
| id | nottingham-51953 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:22:32Z |
| publishDate | 2018 |
| publisher | American Psychiatric Publishing |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-519532020-05-04T19:37:17Z https://eprints.nottingham.ac.uk/51953/ Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression Vulser, Hélène Martinot, Marie-Laure Paillère Artiges, Eric Miranda, Ruben Pentilla, Jani Grimmer, Yvonne van Noort, Betteke M. Stringaris, Argyris Struve, Maren Fadai, Tahmine Kappel, Viola Goodman, Robert Tzavara, Eleni Massaad, Charbel Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Brühl, Rüdiger Büchel, Christian Cattrell, Anna Conrod, Patricia Desrivieres, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomáš Proustka, Louise Rodehacke, Sarah Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Martinot, Jean-Luc Lemaitre, Hervé Objective: White matter microstructure alterations have recently been associated with adolescence depressive episodes, but it is unknown whether they predate depression. We investigated whether subthreshold-depression in adolescence is associated with white matter microstructure variations and whether they relate to depression outcome. Method: Adolescents with subthreshold-depression (n=96) and healthy controls (n=336), drawn from a community-based cohort, were compared using diffusion tensor imaging and whole-brain tractbased spatial statistics (TBSS) at age 14 to assess white matter microstructure. They were followedup at age 16 to assess depression. Probabilistic tractography was used to reconstruct white matter streamlines from the TBSS analysis resulting regions, and along bundles implicated in emotion regulation, the uncinate fasciculus and the cingulum. We searched for mediating effects of white matter microstructure on the relationship between baseline subthreshold-depression and depression at follow-up, and then explored the specificity of the findings. Results: Lower fractional anisotropy (FA) and higher radial diffusivity were found in the anterior corpus callosum in the adolescents with subthreshold-depression. Tractography analysis showed that they also had lower FA in the right cingulum streamlines, along with lower FA and higher mean diffusivity in tracts connecting the corpus callosum to the anterior cingulate cortex. The relation between baseline subthreshold-depression and follow-up depression was mediated by FA values in the latter tracts, and lower FA values in those tracts distinctively predicted higher individual risk for depression. Conclusions: Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex might denote higher risk of transition to depression in adolescents. American Psychiatric Publishing 2018-05-21 Article PeerReviewed Vulser, Hélène, Martinot, Marie-Laure Paillère, Artiges, Eric, Miranda, Ruben, Pentilla, Jani, Grimmer, Yvonne, van Noort, Betteke M., Stringaris, Argyris, Struve, Maren, Fadai, Tahmine, Kappel, Viola, Goodman, Robert, Tzavara, Eleni, Massaad, Charbel, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Brühl, Rüdiger, Büchel, Christian, Cattrell, Anna, Conrod, Patricia, Desrivieres, Sylvane, Flor, Herta, Frouin, Vincent, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Nees, Frauke, Papadopoulos-Orfanos, Dimitri, Paus, Tomáš, Proustka, Louise, Rodehacke, Sarah, Smolka, Michael N., Walter, Henrik, Whelan, Robert, Schumann, Gunter, Martinot, Jean-Luc and Lemaitre, Hervé (2018) Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression. American Journal of Psychiatry . ISSN 1535-7228 (In Press) |
| spellingShingle | Vulser, Hélène Martinot, Marie-Laure Paillère Artiges, Eric Miranda, Ruben Pentilla, Jani Grimmer, Yvonne van Noort, Betteke M. Stringaris, Argyris Struve, Maren Fadai, Tahmine Kappel, Viola Goodman, Robert Tzavara, Eleni Massaad, Charbel Banaschewski, Tobias Barker, Gareth J. Bokde, Arun L.W. Bromberg, Uli Brühl, Rüdiger Büchel, Christian Cattrell, Anna Conrod, Patricia Desrivieres, Sylvane Flor, Herta Frouin, Vincent Gallinat, Jürgen Garavan, Hugh Gowland, Penny Heinz, Andreas Nees, Frauke Papadopoulos-Orfanos, Dimitri Paus, Tomáš Proustka, Louise Rodehacke, Sarah Smolka, Michael N. Walter, Henrik Whelan, Robert Schumann, Gunter Martinot, Jean-Luc Lemaitre, Hervé Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title | Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title_full | Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title_fullStr | Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title_full_unstemmed | Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title_short | Early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| title_sort | early variations in white matter microstructure and depression outcome in adolescents with subthreshold-depression |
| url | https://eprints.nottingham.ac.uk/51953/ |