New therapeutic targets for osteoarthritis pain
Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all j...
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| Format: | Article |
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Sage
2017
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| Online Access: | https://eprints.nottingham.ac.uk/51924/ |
| _version_ | 1848798605537705984 |
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| author | Walsh, David A. Stocks, Joanne |
| author_facet | Walsh, David A. Stocks, Joanne |
| author_sort | Walsh, David A. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Medications that might reduce pain by slowing or preventing structural disease remain elusive. Our increasing understanding of the complex mechanisms that underlie OA pain offers a wide range of potential new treatment targets. New drugs for OA pain might come from repurposing those developed for other conditions, as well as novel compounds targeting pain mechanisms specific to the joint. Here we discuss the mechanisms of OA pain and its therapeutic implications. We explore evolving treatment modalities, including combination treatment. We review recent research and patents pointing to future OA therapies. We discuss the potential for biomarkers to facilitate drug development and targeting. |
| first_indexed | 2025-11-14T20:22:26Z |
| format | Article |
| id | nottingham-51924 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:22:26Z |
| publishDate | 2017 |
| publisher | Sage |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-519242020-05-04T18:49:12Z https://eprints.nottingham.ac.uk/51924/ New therapeutic targets for osteoarthritis pain Walsh, David A. Stocks, Joanne Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Medications that might reduce pain by slowing or preventing structural disease remain elusive. Our increasing understanding of the complex mechanisms that underlie OA pain offers a wide range of potential new treatment targets. New drugs for OA pain might come from repurposing those developed for other conditions, as well as novel compounds targeting pain mechanisms specific to the joint. Here we discuss the mechanisms of OA pain and its therapeutic implications. We explore evolving treatment modalities, including combination treatment. We review recent research and patents pointing to future OA therapies. We discuss the potential for biomarkers to facilitate drug development and targeting. Sage 2017-06-06 Article PeerReviewed Walsh, David A. and Stocks, Joanne (2017) New therapeutic targets for osteoarthritis pain. Slas Discovery, 22 (8). pp. 931-949. ISSN 2472-5552 osteoarthritis pain inflammation osteoclasts peripheral sensitization central sensitizatio http://journals.sagepub.com/doi/10.1177/2472555217716912 doi:10.1177/2472555217716912 doi:10.1177/2472555217716912 |
| spellingShingle | osteoarthritis pain inflammation osteoclasts peripheral sensitization central sensitizatio Walsh, David A. Stocks, Joanne New therapeutic targets for osteoarthritis pain |
| title | New therapeutic targets for osteoarthritis pain |
| title_full | New therapeutic targets for osteoarthritis pain |
| title_fullStr | New therapeutic targets for osteoarthritis pain |
| title_full_unstemmed | New therapeutic targets for osteoarthritis pain |
| title_short | New therapeutic targets for osteoarthritis pain |
| title_sort | new therapeutic targets for osteoarthritis pain |
| topic | osteoarthritis pain inflammation osteoclasts peripheral sensitization central sensitizatio |
| url | https://eprints.nottingham.ac.uk/51924/ https://eprints.nottingham.ac.uk/51924/ https://eprints.nottingham.ac.uk/51924/ |