The Virtual International Stroke Trials Archive
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical tria...
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| Format: | Article |
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American Heart Association
2007
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| Online Access: | https://eprints.nottingham.ac.uk/519/ |
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| author | Myzoon, Ali Bath, Philip M.W. Curram, John Davis, Stephen M. Diener, Hans-Christoph Donnan, Geoffrey A. Fisher, Marc Gregson, Barbara A. Grotta, James Hacke, Werner Hennerici, Michael G. Hommel, Marc Kaste, Markku Marler, John R. Sacco, Ralph L. Teal, Philip Wahlgren, Nils-Gunnar Warach, Steven Weir, Christopher J. Lees, Kennedy R. |
| author_facet | Myzoon, Ali Bath, Philip M.W. Curram, John Davis, Stephen M. Diener, Hans-Christoph Donnan, Geoffrey A. Fisher, Marc Gregson, Barbara A. Grotta, James Hacke, Werner Hennerici, Michael G. Hommel, Marc Kaste, Markku Marler, John R. Sacco, Ralph L. Teal, Philip Wahlgren, Nils-Gunnar Warach, Steven Weir, Christopher J. Lees, Kennedy R. |
| author_sort | Myzoon, Ali |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and
economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs
highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses.
Methods - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing.
Results - ”Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on 15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 6912 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials.
Conclusions - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning. (Stroke. 2007;38:1905-1910.) |
| first_indexed | 2025-11-14T18:12:23Z |
| format | Article |
| id | nottingham-519 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T18:12:23Z |
| publishDate | 2007 |
| publisher | American Heart Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-5192020-05-04T16:26:52Z https://eprints.nottingham.ac.uk/519/ The Virtual International Stroke Trials Archive Myzoon, Ali Bath, Philip M.W. Curram, John Davis, Stephen M. Diener, Hans-Christoph Donnan, Geoffrey A. Fisher, Marc Gregson, Barbara A. Grotta, James Hacke, Werner Hennerici, Michael G. Hommel, Marc Kaste, Markku Marler, John R. Sacco, Ralph L. Teal, Philip Wahlgren, Nils-Gunnar Warach, Steven Weir, Christopher J. Lees, Kennedy R. Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses. Methods - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing. Results - ”Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on 15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 6912 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset-to-treatment time are readily available, and computed tomography lesion data are available for selected trials. Conclusions - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning. (Stroke. 2007;38:1905-1910.) American Heart Association 2007-06-01 Article PeerReviewed Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., Fisher, Marc, Gregson, Barbara A., Grotta, James, Hacke, Werner, Hennerici, Michael G., Hommel, Marc, Kaste, Markku, Marler, John R., Sacco, Ralph L., Teal, Philip, Wahlgren, Nils-Gunnar, Warach, Steven, Weir, Christopher J. and Lees, Kennedy R. (2007) The Virtual International Stroke Trials Archive. Stroke, 38 (6). pp. 1905-1910. clinical trials trial design natural history database modified Rankin Scale National Institutes of Health Stroke Scale |
| spellingShingle | clinical trials trial design natural history database modified Rankin Scale National Institutes of Health Stroke Scale Myzoon, Ali Bath, Philip M.W. Curram, John Davis, Stephen M. Diener, Hans-Christoph Donnan, Geoffrey A. Fisher, Marc Gregson, Barbara A. Grotta, James Hacke, Werner Hennerici, Michael G. Hommel, Marc Kaste, Markku Marler, John R. Sacco, Ralph L. Teal, Philip Wahlgren, Nils-Gunnar Warach, Steven Weir, Christopher J. Lees, Kennedy R. The Virtual International Stroke Trials Archive |
| title | The Virtual International Stroke Trials Archive |
| title_full | The Virtual International Stroke Trials Archive |
| title_fullStr | The Virtual International Stroke Trials Archive |
| title_full_unstemmed | The Virtual International Stroke Trials Archive |
| title_short | The Virtual International Stroke Trials Archive |
| title_sort | virtual international stroke trials archive |
| topic | clinical trials trial design natural history database modified Rankin Scale National Institutes of Health Stroke Scale |
| url | https://eprints.nottingham.ac.uk/519/ |