T cell immunoengineering with advanced biomaterials
Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central...
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| Format: | Article |
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Royal Society of Chemistry
2017
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| Online Access: | https://eprints.nottingham.ac.uk/51872/ |
| _version_ | 1848798593444478976 |
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| author | Delcassian, Derfogail Sattler, Susanne Dunlop, Iain E. |
| author_facet | Delcassian, Derfogail Sattler, Susanne Dunlop, Iain E. |
| author_sort | Delcassian, Derfogail |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central role in the host immune response to these diseases, and so constitute a promising cell type for manipulation. In vivo, T cells are stimulated by antigen presenting cells (APC), therefore to design immunoengineering biomaterials that control T cell behaviour, artificial interfaces that mimic the natural APC-T cell interaction are required. This review draws together research in the design and fabrication of such biomaterial interfaces, and highlights efforts to elucidate key parameters in T cell activation, such as substrate mechanical properties and spatial organization of receptors, illustrating how they can be manipulated by bioengineering approaches to alter T cell function. |
| first_indexed | 2025-11-14T20:22:14Z |
| format | Article |
| id | nottingham-51872 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:22:14Z |
| publishDate | 2017 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-518722020-05-04T18:32:18Z https://eprints.nottingham.ac.uk/51872/ T cell immunoengineering with advanced biomaterials Delcassian, Derfogail Sattler, Susanne Dunlop, Iain E. Recent advances in biomaterials design offer the potential to actively control immune cell activation and behaviour. Many human diseases, such as infections, cancer, and autoimmune disorders, are partly mediated by inappropriate or insufficient activation of the immune system. T cells play a central role in the host immune response to these diseases, and so constitute a promising cell type for manipulation. In vivo, T cells are stimulated by antigen presenting cells (APC), therefore to design immunoengineering biomaterials that control T cell behaviour, artificial interfaces that mimic the natural APC-T cell interaction are required. This review draws together research in the design and fabrication of such biomaterial interfaces, and highlights efforts to elucidate key parameters in T cell activation, such as substrate mechanical properties and spatial organization of receptors, illustrating how they can be manipulated by bioengineering approaches to alter T cell function. Royal Society of Chemistry 2017-03-01 Article PeerReviewed Delcassian, Derfogail, Sattler, Susanne and Dunlop, Iain E. (2017) T cell immunoengineering with advanced biomaterials. Integrative Biology, 9 (3). pp. 211-222. ISSN 1757-9694 http://pubs.rsc.org/en/Content/ArticleLanding/2017/IB/C6IB00233A#!divAbstract doi:10.1039/c6ib00233a doi:10.1039/c6ib00233a |
| spellingShingle | Delcassian, Derfogail Sattler, Susanne Dunlop, Iain E. T cell immunoengineering with advanced biomaterials |
| title | T cell immunoengineering with advanced biomaterials |
| title_full | T cell immunoengineering with advanced biomaterials |
| title_fullStr | T cell immunoengineering with advanced biomaterials |
| title_full_unstemmed | T cell immunoengineering with advanced biomaterials |
| title_short | T cell immunoengineering with advanced biomaterials |
| title_sort | t cell immunoengineering with advanced biomaterials |
| url | https://eprints.nottingham.ac.uk/51872/ https://eprints.nottingham.ac.uk/51872/ https://eprints.nottingham.ac.uk/51872/ |