Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds

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Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds

A series of highly substituted tetrahydrofurans (THFs), decorated with modifiable 2‐aryl, 3‐carboxy and 4‐amino substituents, has been prepared for biological evaluation within the European Lead Factory. Diastereoselective reductive amination of pre‐functionalised 4‐oxofurans, readily prepared from...

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Bibliographic Details
Main Authors:	Moody, Christopher J., Wales, Steven M., Merisor, Elena, Adcock, Holly, Pearce, Christopher A., Strutt, Ian, Lewis, William, Hamza, Daniel
Format:	Article
Language:	English
Published:	Wiley 2018
Subjects:	tetrahydrofurans; pyrrolidines; heterocycles; drug discovery; lead-oriented synthesis
Online Access:	https://eprints.nottingham.ac.uk/51685/

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