Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa

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Rational design and synthesis of modified teixobactin analogues: in vitro antibacterial activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa

Teixobactin, a recently discovered depsipeptide that binds to bacterial lipid II and lipid III, provides a promising molecular scaffold for the design of new antimicrobials. Herein, we describe the synthesis and antimicrobial evaluation of systematically modified teixobactin analogues. The replaceme...

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Bibliographic Details
Main Authors:	Ng, Vivian, Kuehne, Sarah A., Chan, Weng
Format:	Article
Published:	Wiley-VCH Verlag 2018
Subjects:	macrocyclic peptides; lipid II inhibitors; teixobactin; antimicrobial; colistin
Online Access:	https://eprints.nottingham.ac.uk/51669/

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