Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held whic...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
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Portland Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51628/ |
| _version_ | 1848798536263532544 |
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| author | Horsburgh, Karen Wardlaw, Joanna M. van Agtmael, Tom Allan, Stuart M. Ashford, Mike L.J. Bath, Philip M. Brown, Rosalind Berwick, Jason Cader, M. Zameel Carare, Roxana O. Davis, John B. Duncombe, Jessica Farr, Tracy D. Fowler, Jill H. Goense, Jozien Granata, Alessandra Hall, Catherine N. Hainsworth, Atticus H. Harvey, Adam Hawkes, Cheryl A. Joutel, Anne Kalaria, Rajesh N. Kehoe, Patrick G. Lawrence, Catherine B. Lockhart, Andy Love, Seth Macleod, Malcolm R. Macrae, I. Mhairi Markus, Hugh S. McCabe, Chris McColl, Barry W. Meakin, Paul J. Miller, Alyson Nedergaard, Maiken O'Sullivan, Michael Quinn, Terry J. Rajani, Rikesh Saksida, Lisa M. Smith, Colin Smith, Kenneth J. Touyz, Rhian M. Trueman, Rebecca C. Wang, Tao Williams, Anna Williams, Steven C.R. Work, Lorraine M. |
| author_facet | Horsburgh, Karen Wardlaw, Joanna M. van Agtmael, Tom Allan, Stuart M. Ashford, Mike L.J. Bath, Philip M. Brown, Rosalind Berwick, Jason Cader, M. Zameel Carare, Roxana O. Davis, John B. Duncombe, Jessica Farr, Tracy D. Fowler, Jill H. Goense, Jozien Granata, Alessandra Hall, Catherine N. Hainsworth, Atticus H. Harvey, Adam Hawkes, Cheryl A. Joutel, Anne Kalaria, Rajesh N. Kehoe, Patrick G. Lawrence, Catherine B. Lockhart, Andy Love, Seth Macleod, Malcolm R. Macrae, I. Mhairi Markus, Hugh S. McCabe, Chris McColl, Barry W. Meakin, Paul J. Miller, Alyson Nedergaard, Maiken O'Sullivan, Michael Quinn, Terry J. Rajani, Rikesh Saksida, Lisa M. Smith, Colin Smith, Kenneth J. Touyz, Rhian M. Trueman, Rebecca C. Wang, Tao Williams, Anna Williams, Steven C.R. Work, Lorraine M. |
| author_sort | Horsburgh, Karen |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized. |
| first_indexed | 2025-11-14T20:21:20Z |
| format | Article |
| id | nottingham-51628 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:21:20Z |
| publishDate | 2018 |
| publisher | Portland Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-516282020-05-04T19:34:30Z https://eprints.nottingham.ac.uk/51628/ Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology Horsburgh, Karen Wardlaw, Joanna M. van Agtmael, Tom Allan, Stuart M. Ashford, Mike L.J. Bath, Philip M. Brown, Rosalind Berwick, Jason Cader, M. Zameel Carare, Roxana O. Davis, John B. Duncombe, Jessica Farr, Tracy D. Fowler, Jill H. Goense, Jozien Granata, Alessandra Hall, Catherine N. Hainsworth, Atticus H. Harvey, Adam Hawkes, Cheryl A. Joutel, Anne Kalaria, Rajesh N. Kehoe, Patrick G. Lawrence, Catherine B. Lockhart, Andy Love, Seth Macleod, Malcolm R. Macrae, I. Mhairi Markus, Hugh S. McCabe, Chris McColl, Barry W. Meakin, Paul J. Miller, Alyson Nedergaard, Maiken O'Sullivan, Michael Quinn, Terry J. Rajani, Rikesh Saksida, Lisa M. Smith, Colin Smith, Kenneth J. Touyz, Rhian M. Trueman, Rebecca C. Wang, Tao Williams, Anna Williams, Steven C.R. Work, Lorraine M. Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized. Portland Press 2018-04-30 Article PeerReviewed Horsburgh, Karen, Wardlaw, Joanna M., van Agtmael, Tom, Allan, Stuart M., Ashford, Mike L.J., Bath, Philip M., Brown, Rosalind, Berwick, Jason, Cader, M. Zameel, Carare, Roxana O., Davis, John B., Duncombe, Jessica, Farr, Tracy D., Fowler, Jill H., Goense, Jozien, Granata, Alessandra, Hall, Catherine N., Hainsworth, Atticus H., Harvey, Adam, Hawkes, Cheryl A., Joutel, Anne, Kalaria, Rajesh N., Kehoe, Patrick G., Lawrence, Catherine B., Lockhart, Andy, Love, Seth, Macleod, Malcolm R., Macrae, I. Mhairi, Markus, Hugh S., McCabe, Chris, McColl, Barry W., Meakin, Paul J., Miller, Alyson, Nedergaard, Maiken, O'Sullivan, Michael, Quinn, Terry J., Rajani, Rikesh, Saksida, Lisa M., Smith, Colin, Smith, Kenneth J., Touyz, Rhian M., Trueman, Rebecca C., Wang, Tao, Williams, Anna, Williams, Steven C.R. and Work, Lorraine M. (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. Clinical Science, 132 (8). pp. 851-868. ISSN 0143-5221 http://www.clinsci.org/content/132/8/851 doi:10.1042/CS20171620 doi:10.1042/CS20171620 |
| spellingShingle | Horsburgh, Karen Wardlaw, Joanna M. van Agtmael, Tom Allan, Stuart M. Ashford, Mike L.J. Bath, Philip M. Brown, Rosalind Berwick, Jason Cader, M. Zameel Carare, Roxana O. Davis, John B. Duncombe, Jessica Farr, Tracy D. Fowler, Jill H. Goense, Jozien Granata, Alessandra Hall, Catherine N. Hainsworth, Atticus H. Harvey, Adam Hawkes, Cheryl A. Joutel, Anne Kalaria, Rajesh N. Kehoe, Patrick G. Lawrence, Catherine B. Lockhart, Andy Love, Seth Macleod, Malcolm R. Macrae, I. Mhairi Markus, Hugh S. McCabe, Chris McColl, Barry W. Meakin, Paul J. Miller, Alyson Nedergaard, Maiken O'Sullivan, Michael Quinn, Terry J. Rajani, Rikesh Saksida, Lisa M. Smith, Colin Smith, Kenneth J. Touyz, Rhian M. Trueman, Rebecca C. Wang, Tao Williams, Anna Williams, Steven C.R. Work, Lorraine M. Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title | Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title_full | Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title_fullStr | Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title_full_unstemmed | Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title_short | Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| title_sort | small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology |
| url | https://eprints.nottingham.ac.uk/51628/ https://eprints.nottingham.ac.uk/51628/ https://eprints.nottingham.ac.uk/51628/ |