Whole brain comparative anatomy using connectivity blueprints
Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
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eLife Sciences Publications
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51616/ |
| _version_ | 1848798533471174656 |
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| author | Mars, Rogier B. Sotiropoulos, Stamatios N. Passingham, Richard E. Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A. Sibson, Nicola Jbabdi, Saad |
| author_facet | Mars, Rogier B. Sotiropoulos, Stamatios N. Passingham, Richard E. Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A. Sibson, Nicola Jbabdi, Saad |
| author_sort | Mars, Rogier B. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains. |
| first_indexed | 2025-11-14T20:21:17Z |
| format | Article |
| id | nottingham-51616 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:21:17Z |
| publishDate | 2018 |
| publisher | eLife Sciences Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-516162020-05-04T19:36:13Z https://eprints.nottingham.ac.uk/51616/ Whole brain comparative anatomy using connectivity blueprints Mars, Rogier B. Sotiropoulos, Stamatios N. Passingham, Richard E. Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A. Sibson, Nicola Jbabdi, Saad Comparing the brains of related species faces the challenges of establishing homologies whilst accommodating evolutionary specializations. Here we propose a general framework for understanding similarities and differences between the brains of primates. The approach uses white matter blueprints of the whole cortex based on a set of white matter tracts that can be anatomically matched across species. The blueprints provide a common reference space that allows us to navigate between brains of different species, identify homologous cortical areas, or to transform whole cortical maps from one species to the other. Specializations are cast within this framework as deviations between the species’ blueprints. We illustrate how this approach can be used to compare human and macaque brains. eLife Sciences Publications 2018-05-11 Article PeerReviewed Mars, Rogier B., Sotiropoulos, Stamatios N., Passingham, Richard E., Sallet, Jerome, Verhagen, Lennart, Khrapitchev, Alexandre A., Sibson, Nicola and Jbabdi, Saad (2018) Whole brain comparative anatomy using connectivity blueprints. eLife, 7 . e35237/1-e35237/15. ISSN 2050-084X https://elifesciences.org/articles/35237 doi:10.7554/eLife.35237 doi:10.7554/eLife.35237 |
| spellingShingle | Mars, Rogier B. Sotiropoulos, Stamatios N. Passingham, Richard E. Sallet, Jerome Verhagen, Lennart Khrapitchev, Alexandre A. Sibson, Nicola Jbabdi, Saad Whole brain comparative anatomy using connectivity blueprints |
| title | Whole brain comparative anatomy using connectivity blueprints |
| title_full | Whole brain comparative anatomy using connectivity blueprints |
| title_fullStr | Whole brain comparative anatomy using connectivity blueprints |
| title_full_unstemmed | Whole brain comparative anatomy using connectivity blueprints |
| title_short | Whole brain comparative anatomy using connectivity blueprints |
| title_sort | whole brain comparative anatomy using connectivity blueprints |
| url | https://eprints.nottingham.ac.uk/51616/ https://eprints.nottingham.ac.uk/51616/ https://eprints.nottingham.ac.uk/51616/ |