Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort
The Brains for Dementia Research project is a recently established cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demo...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
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IOS Press
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51523/ |
| _version_ | 1848798515365412864 |
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| author | Brookes, Keeley J. McConnell, G. Williams, K. Chaudhury, Sultan R Madhan, G. Patel, T. Turley, C. Guetta-Baranes, Tamar Francis, Paul T. Morgan, Kevin |
| author_facet | Brookes, Keeley J. McConnell, G. Williams, K. Chaudhury, Sultan R Madhan, G. Patel, T. Turley, C. Guetta-Baranes, Tamar Francis, Paul T. Morgan, Kevin |
| author_sort | Brookes, Keeley J. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | The Brains for Dementia Research project is a recently established cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ε4 allele was identified (P=3.99x10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al GWAS meta-analysis was observed. |
| first_indexed | 2025-11-14T20:21:00Z |
| format | Article |
| id | nottingham-51523 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:21:00Z |
| publishDate | 2018 |
| publisher | IOS Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-515232020-05-04T19:41:16Z https://eprints.nottingham.ac.uk/51523/ Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort Brookes, Keeley J. McConnell, G. Williams, K. Chaudhury, Sultan R Madhan, G. Patel, T. Turley, C. Guetta-Baranes, Tamar Francis, Paul T. Morgan, Kevin The Brains for Dementia Research project is a recently established cohort which aims to provide brain tissue for research purposes from neuropathologically defined samples. Here we present the findings from our analysis on the 19 established GWAS index SNPs for Alzheimer’s disease, in order to demonstrate if the BDR sample also displays association to these variants. A highly significant association of the APOE ε4 allele was identified (P=3.99x10-12). Association tests for the 19 GWAS SNPs found that although no SNPs survive multiple testing, nominal significant findings were detected and concordance with the Lambert et al GWAS meta-analysis was observed. IOS Press 2018-06-19 Article PeerReviewed Brookes, Keeley J., McConnell, G., Williams, K., Chaudhury, Sultan R, Madhan, G., Patel, T., Turley, C., Guetta-Baranes, Tamar, Francis, Paul T. and Morgan, Kevin (2018) Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort. Journal of Alzheimer's Disease, 64 (2). pp. 355-362. ISSN 1387-2877 Alzheimer’s disease association Brains for Dementia Research genome-wide association study single nucleotide polymorphisms https://content.iospress.com/articles/journal-of-alzheimers-disease/jad180191 doi:10.3233/JAD-180191 doi:10.3233/JAD-180191 |
| spellingShingle | Alzheimer’s disease association Brains for Dementia Research genome-wide association study single nucleotide polymorphisms Brookes, Keeley J. McConnell, G. Williams, K. Chaudhury, Sultan R Madhan, G. Patel, T. Turley, C. Guetta-Baranes, Tamar Francis, Paul T. Morgan, Kevin Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title | Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title_full | Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title_fullStr | Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title_full_unstemmed | Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title_short | Genotyping of the Alzheimer’s disease Genome-Wide Association Study index single nucleotide polymorphisms in the Brains for Dementia research cohort |
| title_sort | genotyping of the alzheimer’s disease genome-wide association study index single nucleotide polymorphisms in the brains for dementia research cohort |
| topic | Alzheimer’s disease association Brains for Dementia Research genome-wide association study single nucleotide polymorphisms |
| url | https://eprints.nottingham.ac.uk/51523/ https://eprints.nottingham.ac.uk/51523/ https://eprints.nottingham.ac.uk/51523/ |