Testicular function and bone in young men with severe childhood-onset obesity.
Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puberty. Methods: A cohort of adolescent and young adu...
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| Format: | Article |
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Karger
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51489/ |
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| author | Anand-Ivell, Ravinder Ivell, Richard Laakso, Saila Viljakainen, Heli Lipsanen-Nyman, Marita Turpeinen, Ursula Ivaska, Kaisa K Mäkitie, Outi |
| author_facet | Anand-Ivell, Ravinder Ivell, Richard Laakso, Saila Viljakainen, Heli Lipsanen-Nyman, Marita Turpeinen, Ursula Ivaska, Kaisa K Mäkitie, Outi |
| author_sort | Anand-Ivell, Ravinder |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puberty.
Methods: A cohort of adolescent and young adult males with severe childhood-onset obesity (n=21, mean age 18.5 yrs) and an age-matched control group were assessed for testicular hormones and DXA-derived bone mass.
Results: Current median body mass indexes for the obese and control subjects were 37.4 kg/m2 and 22.9 kg/m2. Severe early-onset obesity manifested with lower free testosterone [median (inter-quartile range) 244 (194–332) vs. 403 (293–463) pmol/l, P=0.002]. Lower insulin-like 3 [1.02 (0.82–1.23) vs. 1.22 (1.01–1.46) ng/mL, P=0.045] and lower ratio of testosterone to LH [2.81 (1.96 – 3.98) vs. 4.10 (3.03 – 5.83) nM/IU, P=0.008] suggested disrupted Leydig cell function. Degree of current obesity correlated inversely with free testosterone (τ=-0.516, P=0.003), which in turn correlated positively with bone area at all measurement sites in males with childhood-onset obesity.
Conclusions: Severe childhood-onset obesity associates with impaired Leydig cell function in young men and lower free testosterone may contribute to impaired bone growth. |
| first_indexed | 2025-11-14T20:20:52Z |
| format | Article |
| id | nottingham-51489 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:20:52Z |
| publishDate | 2018 |
| publisher | Karger |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-514892020-04-29T16:02:41Z https://eprints.nottingham.ac.uk/51489/ Testicular function and bone in young men with severe childhood-onset obesity. Anand-Ivell, Ravinder Ivell, Richard Laakso, Saila Viljakainen, Heli Lipsanen-Nyman, Marita Turpeinen, Ursula Ivaska, Kaisa K Mäkitie, Outi Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puberty. Methods: A cohort of adolescent and young adult males with severe childhood-onset obesity (n=21, mean age 18.5 yrs) and an age-matched control group were assessed for testicular hormones and DXA-derived bone mass. Results: Current median body mass indexes for the obese and control subjects were 37.4 kg/m2 and 22.9 kg/m2. Severe early-onset obesity manifested with lower free testosterone [median (inter-quartile range) 244 (194–332) vs. 403 (293–463) pmol/l, P=0.002]. Lower insulin-like 3 [1.02 (0.82–1.23) vs. 1.22 (1.01–1.46) ng/mL, P=0.045] and lower ratio of testosterone to LH [2.81 (1.96 – 3.98) vs. 4.10 (3.03 – 5.83) nM/IU, P=0.008] suggested disrupted Leydig cell function. Degree of current obesity correlated inversely with free testosterone (τ=-0.516, P=0.003), which in turn correlated positively with bone area at all measurement sites in males with childhood-onset obesity. Conclusions: Severe childhood-onset obesity associates with impaired Leydig cell function in young men and lower free testosterone may contribute to impaired bone growth. Karger 2018-04-29 Article PeerReviewed Anand-Ivell, Ravinder, Ivell, Richard, Laakso, Saila, Viljakainen, Heli, Lipsanen-Nyman, Marita, Turpeinen, Ursula, Ivaska, Kaisa K and Mäkitie, Outi (2018) Testicular function and bone in young men with severe childhood-onset obesity. Hormone Research in Paediatrics . ISSN 1663-2826 (In Press) Boys metabolism sex hormones puberty testosterone INSL3 |
| spellingShingle | Boys metabolism sex hormones puberty testosterone INSL3 Anand-Ivell, Ravinder Ivell, Richard Laakso, Saila Viljakainen, Heli Lipsanen-Nyman, Marita Turpeinen, Ursula Ivaska, Kaisa K Mäkitie, Outi Testicular function and bone in young men with severe childhood-onset obesity. |
| title | Testicular function and bone in young men with severe childhood-onset obesity. |
| title_full | Testicular function and bone in young men with severe childhood-onset obesity. |
| title_fullStr | Testicular function and bone in young men with severe childhood-onset obesity. |
| title_full_unstemmed | Testicular function and bone in young men with severe childhood-onset obesity. |
| title_short | Testicular function and bone in young men with severe childhood-onset obesity. |
| title_sort | testicular function and bone in young men with severe childhood-onset obesity. |
| topic | Boys metabolism sex hormones puberty testosterone INSL3 |
| url | https://eprints.nottingham.ac.uk/51489/ |