Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case

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Lipophilicity predicts the ability of nonsulphonylurea drugs to block pancreatic beta-cell KATP channels and stimulate insulin secretion: statins as a test case

Aims KATP ion channels play a key role in glucose‐stimulated insulin secretion. However, many drugs block KATP as “off targets” leading to hyperinsulinaemia and hypoglycaemia. As such drugs are often lipophilic, the aim was to examine the relationship between drug lipophilicity (P) and IC50 for K...

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Bibliographic Details
Main Authors:	Real, Joana, Miranda, Caroline, Olofsson, Charlotta S., Smith, Paul A.
Format:	Article
Language:	English
Published:	Wiley 2018
Subjects:	Beta cell; Insulin; KATP channel; Simvastatin
Online Access:	https://eprints.nottingham.ac.uk/51403/

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