Drug delivery across length scales
Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic...
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| Format: | Article |
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Taylor & Francis
2018
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| Online Access: | https://eprints.nottingham.ac.uk/51368/ |
| _version_ | 1848798481467047936 |
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| author | Delcassian, Derfogail Patel, Asha K. Cortinas, Abel B. Langer, Robert |
| author_facet | Delcassian, Derfogail Patel, Asha K. Cortinas, Abel B. Langer, Robert |
| author_sort | Delcassian, Derfogail |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic acids. The use of potent drugs which target specific organs, cells or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets. Here, we review the miniaturisation of drug delivery systems from the macro to nano-scale, focussing on controlled dosing and controlled targeting as two key parameters in drug delivery device design. We describe how the miniaturisation of these devices enables the move from repeated, systemic dosing, to on-demand, targeted delivery of therapeutic drugs and highlight areas of focus for the future. |
| first_indexed | 2025-11-14T20:20:27Z |
| format | Article |
| id | nottingham-51368 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:20:27Z |
| publishDate | 2018 |
| publisher | Taylor & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-513682020-05-04T19:32:50Z https://eprints.nottingham.ac.uk/51368/ Drug delivery across length scales Delcassian, Derfogail Patel, Asha K. Cortinas, Abel B. Langer, Robert Over the last century, there has been a dramatic change in the nature of therapeutic, biologically active molecules available to treat disease. Therapies have evolved from extracted natural products towards rationally designed biomolecules, including small molecules, engineered proteins and nucleic acids. The use of potent drugs which target specific organs, cells or biochemical pathways, necessitates new tools which can enable controlled delivery and dosing of these therapeutics to their biological targets. Here, we review the miniaturisation of drug delivery systems from the macro to nano-scale, focussing on controlled dosing and controlled targeting as two key parameters in drug delivery device design. We describe how the miniaturisation of these devices enables the move from repeated, systemic dosing, to on-demand, targeted delivery of therapeutic drugs and highlight areas of focus for the future. Taylor & Francis 2018-02-20 Article PeerReviewed Delcassian, Derfogail, Patel, Asha K., Cortinas, Abel B. and Langer, Robert (2018) Drug delivery across length scales. Journal of Drug Targeting, 27 (3). pp. 229-243. ISSN 1029-2330 Drug delivery length scale targeting macro micro nano https://www.tandfonline.com/doi/full/10.1080/1061186X.2018.1438440 doi:10.1080/1061186X.2018.1438440 doi:10.1080/1061186X.2018.1438440 |
| spellingShingle | Drug delivery length scale targeting macro micro nano Delcassian, Derfogail Patel, Asha K. Cortinas, Abel B. Langer, Robert Drug delivery across length scales |
| title | Drug delivery across length scales |
| title_full | Drug delivery across length scales |
| title_fullStr | Drug delivery across length scales |
| title_full_unstemmed | Drug delivery across length scales |
| title_short | Drug delivery across length scales |
| title_sort | drug delivery across length scales |
| topic | Drug delivery length scale targeting macro micro nano |
| url | https://eprints.nottingham.ac.uk/51368/ https://eprints.nottingham.ac.uk/51368/ https://eprints.nottingham.ac.uk/51368/ |