Disease modeling hypertrophic cardiomyopathy using CRISPR/Cas9 genome editing technology in human pluripotent stem cell-derived cardiomyocytes

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Disease modeling hypertrophic cardiomyopathy using CRISPR/Cas9 genome editing technology in human pluripotent stem cell-derived cardiomyocytes

Hypertrophic cardiomyopathy (HCM) is a prevalent genetic cardiovascular disease affecting 1:500 individuals whose cardiac function is deteriorated due to thickening of the left ventricle of the heart, mostly owing to mutations in sarcomeric genes. Modeling HCM in vitro using human pluripotent stem c...

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Bibliographic Details
Main Author:	Mosqueira, Diogo
Format:	Thesis (University of Nottingham only)
Language:	English
Published:	2018
Subjects:	Hypertrophic cardiomyopathy; disease modelling; CRISPR/Cas9; genome-edited human pluripotent stem cell-cardiomyocytes; R453C-βMHC
Online Access:	https://eprints.nottingham.ac.uk/51359/

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