How to characterize the function of a brain region
Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the heterogenei...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Published: |
Elsevier
2018
|
| Subjects: | |
| Online Access: | https://eprints.nottingham.ac.uk/51332/ |
| _version_ | 1848798471783448576 |
|---|---|
| author | Genon, Sarah Reid, Andrew Langner, Robert Amunts, Katrin Eickhoff, Simon B. |
| author_facet | Genon, Sarah Reid, Andrew Langner, Robert Amunts, Katrin Eickhoff, Simon B. |
| author_sort | Genon, Sarah |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the heterogeneity of associations could be harnessed to disclose the computational function of any region. Aggregating activation data from neuroimaging studies allows us to characterize the functional engagement of a region across a range of experimental conditions. Furthermore, large-sample data can disclose covariation between brain region features and ecological behavioral phenotyping. Combining these two approaches opens a new perspective to determine the behavioral associations of a brain region, and hence its function and broader role within large-scale functional networks. |
| first_indexed | 2025-11-14T20:20:18Z |
| format | Article |
| id | nottingham-51332 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:20:18Z |
| publishDate | 2018 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-513322020-05-04T19:34:25Z https://eprints.nottingham.ac.uk/51332/ How to characterize the function of a brain region Genon, Sarah Reid, Andrew Langner, Robert Amunts, Katrin Eickhoff, Simon B. Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the heterogeneity of associations could be harnessed to disclose the computational function of any region. Aggregating activation data from neuroimaging studies allows us to characterize the functional engagement of a region across a range of experimental conditions. Furthermore, large-sample data can disclose covariation between brain region features and ecological behavioral phenotyping. Combining these two approaches opens a new perspective to determine the behavioral associations of a brain region, and hence its function and broader role within large-scale functional networks. Elsevier 2018-04-30 Article PeerReviewed Genon, Sarah, Reid, Andrew, Langner, Robert, Amunts, Katrin and Eickhoff, Simon B. (2018) How to characterize the function of a brain region. Trends in Cognitive Sciences, 22 (4). pp. 350-364. ISSN 1879-307X Functional specialization; Data-driven; Brain mapping; MRI; Neurosynth; BrainMap https://doi.org/10.1016/j.tics.2018.01.010 doi:10.1016/j.tics.2018.01.010 doi:10.1016/j.tics.2018.01.010 |
| spellingShingle | Functional specialization; Data-driven; Brain mapping; MRI; Neurosynth; BrainMap Genon, Sarah Reid, Andrew Langner, Robert Amunts, Katrin Eickhoff, Simon B. How to characterize the function of a brain region |
| title | How to characterize the function of a brain region |
| title_full | How to characterize the function of a brain region |
| title_fullStr | How to characterize the function of a brain region |
| title_full_unstemmed | How to characterize the function of a brain region |
| title_short | How to characterize the function of a brain region |
| title_sort | how to characterize the function of a brain region |
| topic | Functional specialization; Data-driven; Brain mapping; MRI; Neurosynth; BrainMap |
| url | https://eprints.nottingham.ac.uk/51332/ https://eprints.nottingham.ac.uk/51332/ https://eprints.nottingham.ac.uk/51332/ |