Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by release of a cationic serine protease inhibitor

Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing...

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Bibliographic Details
Main Authors: Limón, David, Jiménez-Newman, Claire, Calpena, Ana C., González-Campo, Arántzazu, Amabilino, David B., Pérez-Garcia, Lluïsa
Format: Article
Published: Royal Society of Chemistry 2017
Online Access:https://eprints.nottingham.ac.uk/51297/
Description
Summary:Gels formed by a gemini dicationic amphiphile incorporate a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, within the fibres as well as in the space between them, affecting a number of gel properties but most importantly inducing remarkable fibre coiling at the microscopic level as a result of drug releasefrom the gel. Drug release and skin permeation experiments show its potential for topical administration.