Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases

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Multifunctional serine protease inhibitor-coated water-soluble gold nanoparticles as a novel targeted approach for the treatment of inflammatory skin diseases

The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme—such as 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF·HCl) or the anti-human recombinant Kallikre...

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Bibliographic Details
Main Authors:	Limón, David, Fábrega, María José, Calpena, Ana C., Badia, Josefa, Baldomà, Laura, Pérez-García, Lluïsa
Format:	Article
Language:	English
Published:	American Chemical Society 2018
Subjects:	Serine protease inhibitors ; Water soluble gold nanoparticles ; Skin diseases ; Drug delivery ; Kallikrein ; Keratinocytes ; Rosacea.
Online Access:	https://eprints.nottingham.ac.uk/51295/

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