Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery

QR Code

Synthesis of highly substituted 1,2-diazetidin-3-ones, small ring scaffolds for drug discovery

1,2-Diazetidin-3-ones are readily accessible, small ring scaffolds that upon functionalization have the potential to produce diverse 3-dimensional structures for drug discovery. Thus treatment of diazo hydrazides, obtained from simple hydrazides and malonyl half ester derivatives, followed by diazo...

Full description

Bibliographic Details
Main Authors:	Santos, Marilla S., Nortcliffe, Andrew, Lewis, William, Bradshaw, Tracey D, Moody, Christopher J.
Format:	Article
Language:	English
Published:	Wiley-VCH Verlag 2018
Online Access:	https://eprints.nottingham.ac.uk/51269/

Similar Items

Seven-membered ring scaffolds for drug discovery: access to functionalised azepanes and oxepanes through diazocarbonyl chemistry
by: Nortcliffe, Andrew, et al.
Published: (2015)

C–H insertion as a key step to spiro-oxetanes, scaffolds for drug discovery
by: Nicolle, Simon M., et al.
Published: (2017)

Densely functionalised spirocyclic oxetane-piperidine scaffolds for drug discovery
by: Geary, Gemma C., et al.
Published: (2017)

Diastereoselective synthesis of highly substituted, amino- and pyrrolidino-tetrahydrofurans as lead-like molecular scaffolds
by: Moody, Christopher J., et al.
Published: (2018)

Cuprate addition to a 6-substituted pentafulvene: preparation of sec-alkyl substituted titanocene dichlorides and their biological activity
by: Cini, Melchior, et al.
Published: (2013)

Stereoselective synthesis of highly substituted tetrahydrofurans by diverted carbene O–H insertion reaction
by: Nicolle, Simon M., et al.
Published: (2015)

Preparation of Substituted Imidazolidinones and Hydantoins by Ring-Expansion of Aziridinones
by: M. M., Yusoff, et al.
Published: (1997)

Kinase targets in CNS drug discovery
by: Gunosewoyo, Hendra, et al.
Published: (2017)

The importance of in-silico studies in drug discovery
by: Roney, Miah, et al.
Published: (2024)

The evolutionary development in drug discovery and delivery
by: Ithnin, Hairuszah, et al.
Published: (2013)

Discovery service as one stop information services
by: Abdullah, Sarifah
Published: (2014)

New injectable scaffolds for cell and drug delivery
by: Hamilton, Lloyd George
Published: (2009)

Screening techniques for drug discovery in Alzheimer's disease
by: Maniam, Sandra, et al.
Published: (2024)

In-vitro Evaluation of Chitosan - Hydroxyapatite Nanocomposite Scaffolds as Bone Substitutes with Antibiofilm Properties
by: Lipton, Anuj Nishanth, et al.
Published: (2021)

Synthesis and growth-inhibitory activities of imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position
by: Cousin, David, et al.
Published: (2018)

AI-Based Drug Design: Revolutionizing Drug Discovery through in Silico Analysis
by: Yamini Priya, Deepthimahanthi, et al.
Published: (2023)

A practical drug discovery project at the undergraduate level
by: Fray, Michael J., et al.
Published: (2013)

The structural modification of natural products for novel drug discovery
by: Yao, Hong, et al.
Published: (2016)

Diversification of ortho-fused cycloocta-2,5-dien-1-one cores and 8 to 6-Ring conversion by sigma bond C-C cleavage
by: Eccleshare, Lee, et al.
Published: (2016)

Development of a series of bis-triazoles as G-quadruplex ligands
by: Saleh, Maysaa, et al.
Published: (2017)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-a][1,3,5]triazines
by: Lim, Felicia Phei Lin, et al.
Published: (2018)

A one-pot, multicomponent reaction for the synthesis of novel 2-alkyl substituted 4-aminoimidazo[1,2-: A] [1,3,5]triazines
by: Lim, F., et al.
Published: (2018)

Montmorillonite-based polyacrylamide hydrogel rings for controlled vaginal drug delivery
by: Sharifzadeh, Ghorbanali, et al.
Published: (2020)

Phytochemical screening expedition 2009 : drug discovery from nature.
by: Mat So'ad, Siti Zaiton, et al.
Published: (2011)

The fourth international Peptide Symposium: Discovery to Drugs: The Peptide Pipeline
by: Benson, Heather, et al.
Published: (2008)

Developing Science Gateways for Drug Discovery in a Grid Environment
by: Pérez‑Sánchez, Horacio, et al.
Published: (2016)

Nucleoside based self-assembling drugs for localized drug delivery
by: Skilling, Kathryn J., et al.
Published: (2018)

Asymmetric pentafulvene carbometalation-access to enantiopure titanocene dichlorides of biological relevance
by: Cini, Melchior, et al.
Published: (2015)

An injectable degradable porous polymer scaffold for tissue engineering and drug delivery
by: Salem, Aliasger K.
Published: (2002)

Green synthesis of benzimidazole scaffolds using copper-substituted zinc aluminate in a sol-gel process
by: Kadam, Uttam D., et al.
Published: (2025)

The use of cell culture technique in small molecule antidiabetes drug discovery
by: Bakhtiar, M. Taher
Published: (2019)

Biased agonism in drug discovery: is it too soon to choose a path?
by: Michel, Martin C., et al.
Published: (2018)

A brief review of drug discovery research for Human African Trypanosomiasis
by: Cullen, Danica, et al.
Published: (2017)

Haruan Channa striatus: a drug discovery in an AGRO-industry setting
by: Mat Jais, Abdul Manan
Published: (2010)

Drug discovery and development: a historical overview, current challenges and perspectives
by: Yu, Chai Xin, et al.
Published: (2024)

Structure, degradation, drug release and mechanical properties relationships of iron-based drug eluting scaffolds: The effects of PLGA
by: Yusop, Abdul Hakim, et al.
Published: (2018)

Three Dimensional Printed Immunomodulatory Scaffolds with Controlled Drug Release for Bone Regeneration
by: Majrashi, Majed
Published: (2023)

Synthesis and crystallographic characterisation of pyridyl- and indoleninyl-substituted pyrimido[1,2-b]indazoles
by: Ramle, Abdul Qaiyum, et al.
Published: (2022)

Synthesis of nitrogen-substituted pyran-2-ones via radical cyclisation approach
by: Mohd Nor, Siti Mariam, et al.
Published: (2013)

Discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach
by: Ahmad, Siti Junaidah, et al.
Published: (2017)