Switchable synthesis of Z-homoallylic boronates and E-allylic boronates by enantioselective copper-catalyzed 1,6-boration

Switchable synthesis of Z-homoallylic boronates and E-allylic boronates by enantioselective copper-catalyzed 1,6-boration

The enantioselective Cu-catalyzed 1,6-boration of (E,E) α,β,γ,δ-unsaturated ketones is described, which gives homoallylic boronates with high enantiomeric purity and unexpectedly high Zselectivity. By changing the solvent, the outcome can be altered to give E-allylic boronates.

Bibliographic Details
Main Authors: Luo, Yunfei, Wales, Steven M., Korkis, Stamatis E., Roy, Iain D., Lewis, William, Lam, Hon Wai
Format: Article
Published: Wiley 2018
Subjects:
1
6-addition; asymmetric catalysis; boron; copper; enantioselectivity
Online Access:https://eprints.nottingham.ac.uk/51268/

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