Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence

Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence

Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. Methods: In the present study, we investigated this issue using a large sam...

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Main Authors: Baker, Travis E., Castellanos-Ryan, Natalie, Schumann, Gunter, Cattrell, Anna, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun L.W., Whelan, Rob, Buechel, Christian, Bromberg, Uli, Orfanos, Dimitri Papadopoulos, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Brühl, Rüdiger, Gowland, Penny A., Paus, Tomáš, Poustka, Luise, Martinot, Jean-Luc, Lemaitre, Hervé, Artiges, Eric, Martinot, Marie-Laure Paillère, Smolka, Michael N., Conrod, Patricia J.
Format: Article
Published: Cambridge University Press 2018
Subjects:
adolescence; dopamine D1/D2 receptor; ventral striatum; orbital frontal cortex; reward; addiction
Online Access:https://eprints.nottingham.ac.uk/51240/

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