Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence

Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. Methods: In the present study, we investigated this issue using a large sam...

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Main Authors: Baker, Travis E., Castellanos-Ryan, Natalie, Schumann, Gunter, Cattrell, Anna, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun L.W., Whelan, Rob, Buechel, Christian, Bromberg, Uli, Orfanos, Dimitri Papadopoulos, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Brühl, Rüdiger, Gowland, Penny A., Paus, Tomáš, Poustka, Luise, Martinot, Jean-Luc, Lemaitre, Hervé, Artiges, Eric, Martinot, Marie-Laure Paillère, Smolka, Michael N., Conrod, Patricia J.
Format: Article
Published: Cambridge University Press 2018
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Online Access:https://eprints.nottingham.ac.uk/51240/
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author Baker, Travis E.
Castellanos-Ryan, Natalie
Schumann, Gunter
Cattrell, Anna
Flor, Herta
Nees, Frauke
Banaschewski, Tobias
Bokde, Arun L.W.
Whelan, Rob
Buechel, Christian
Bromberg, Uli
Orfanos, Dimitri Papadopoulos
Gallinat, Jürgen
Garavan, Hugh
Heinz, Andreas
Walter, Henrik
Brühl, Rüdiger
Gowland, Penny A.
Paus, Tomáš
Poustka, Luise
Martinot, Jean-Luc
Lemaitre, Hervé
Artiges, Eric
Martinot, Marie-Laure Paillère
Smolka, Michael N.
Conrod, Patricia J.
author_facet Baker, Travis E.
Castellanos-Ryan, Natalie
Schumann, Gunter
Cattrell, Anna
Flor, Herta
Nees, Frauke
Banaschewski, Tobias
Bokde, Arun L.W.
Whelan, Rob
Buechel, Christian
Bromberg, Uli
Orfanos, Dimitri Papadopoulos
Gallinat, Jürgen
Garavan, Hugh
Heinz, Andreas
Walter, Henrik
Brühl, Rüdiger
Gowland, Penny A.
Paus, Tomáš
Poustka, Luise
Martinot, Jean-Luc
Lemaitre, Hervé
Artiges, Eric
Martinot, Marie-Laure Paillère
Smolka, Michael N.
Conrod, Patricia J.
author_sort Baker, Travis E.
building Nottingham Research Data Repository
collection Online Access
description Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. Methods: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic polymorphisms of the D1 and D2 receptor type on the reward function of the ventral striatum and orbital frontal cortex, and whether this relationship predicted the propensity to engage in early alcohol misuse behaviours at 14 years of age and again at 16 years of age. Results: The results demonstrated a regional specificity with which the functional polymorphism rs686 of the DRD1 gene and Taq1A of the ANKK1 gene influenced medial and lateral orbital frontal cortex activation during reward anticipation, respectively. Importantly, our path model revealed a significant indirect relationship between the rs686 of the DRD1 gene and early onset of alcohol misuse through a medial orbital frontal cortex and the ventral striatum interaction. Conclusions: These findings highlight the role of D1 and D2 in adjusting reward-related activations within the mesocorticolimbic circuitry, as well as in the susceptibility to early onset of alcohol misuse.
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publishDate 2018
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spelling nottingham-512402020-05-04T19:41:23Z https://eprints.nottingham.ac.uk/51240/ Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence Baker, Travis E. Castellanos-Ryan, Natalie Schumann, Gunter Cattrell, Anna Flor, Herta Nees, Frauke Banaschewski, Tobias Bokde, Arun L.W. Whelan, Rob Buechel, Christian Bromberg, Uli Orfanos, Dimitri Papadopoulos Gallinat, Jürgen Garavan, Hugh Heinz, Andreas Walter, Henrik Brühl, Rüdiger Gowland, Penny A. Paus, Tomáš Poustka, Luise Martinot, Jean-Luc Lemaitre, Hervé Artiges, Eric Martinot, Marie-Laure Paillère Smolka, Michael N. Conrod, Patricia J. Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. Methods: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic polymorphisms of the D1 and D2 receptor type on the reward function of the ventral striatum and orbital frontal cortex, and whether this relationship predicted the propensity to engage in early alcohol misuse behaviours at 14 years of age and again at 16 years of age. Results: The results demonstrated a regional specificity with which the functional polymorphism rs686 of the DRD1 gene and Taq1A of the ANKK1 gene influenced medial and lateral orbital frontal cortex activation during reward anticipation, respectively. Importantly, our path model revealed a significant indirect relationship between the rs686 of the DRD1 gene and early onset of alcohol misuse through a medial orbital frontal cortex and the ventral striatum interaction. Conclusions: These findings highlight the role of D1 and D2 in adjusting reward-related activations within the mesocorticolimbic circuitry, as well as in the susceptibility to early onset of alcohol misuse. Cambridge University Press 2018-06-18 Article PeerReviewed Baker, Travis E., Castellanos-Ryan, Natalie, Schumann, Gunter, Cattrell, Anna, Flor, Herta, Nees, Frauke, Banaschewski, Tobias, Bokde, Arun L.W., Whelan, Rob, Buechel, Christian, Bromberg, Uli, Orfanos, Dimitri Papadopoulos, Gallinat, Jürgen, Garavan, Hugh, Heinz, Andreas, Walter, Henrik, Brühl, Rüdiger, Gowland, Penny A., Paus, Tomáš, Poustka, Luise, Martinot, Jean-Luc, Lemaitre, Hervé, Artiges, Eric, Martinot, Marie-Laure Paillère, Smolka, Michael N. and Conrod, Patricia J. (2018) Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence. Psychological Medicine . ISSN 1469-8978 adolescence; dopamine D1/D2 receptor; ventral striatum; orbital frontal cortex; reward; addiction https://www.cambridge.org/core/journals/psychological-medicine/article/modulation-of-orbitofrontalstriatal-reward-activity-by-dopaminergic-functional-polymorphisms-contributes-to-a-predisposition-to-alcohol-misuse-in-early-adolescence/616F5E24313D3563B324 doi:10.1017/S0033291718001459 doi:10.1017/S0033291718001459
spellingShingle adolescence; dopamine D1/D2 receptor; ventral striatum; orbital frontal cortex; reward; addiction
Baker, Travis E.
Castellanos-Ryan, Natalie
Schumann, Gunter
Cattrell, Anna
Flor, Herta
Nees, Frauke
Banaschewski, Tobias
Bokde, Arun L.W.
Whelan, Rob
Buechel, Christian
Bromberg, Uli
Orfanos, Dimitri Papadopoulos
Gallinat, Jürgen
Garavan, Hugh
Heinz, Andreas
Walter, Henrik
Brühl, Rüdiger
Gowland, Penny A.
Paus, Tomáš
Poustka, Luise
Martinot, Jean-Luc
Lemaitre, Hervé
Artiges, Eric
Martinot, Marie-Laure Paillère
Smolka, Michael N.
Conrod, Patricia J.
Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title_full Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title_fullStr Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title_full_unstemmed Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title_short Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
title_sort modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
topic adolescence; dopamine D1/D2 receptor; ventral striatum; orbital frontal cortex; reward; addiction
url https://eprints.nottingham.ac.uk/51240/
https://eprints.nottingham.ac.uk/51240/
https://eprints.nottingham.ac.uk/51240/