Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor)
Five juvenile pied imperial pigeons (Ducula bicolor) presented with neurological signs including torticollis, ataxia and poor flying ability. All were humanely destroyed and submitted for post-mortem examination. Microscopically, the most significant findings were in the brain and spinal cord. Spher...
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Elsevier
2017
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| Online Access: | https://eprints.nottingham.ac.uk/51126/ |
| _version_ | 1848798422879961088 |
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| author | Barrows, M. Killick, R. Day, C. Saunders, R. Baiker, Kerstin Ressel, L. Denk, D. |
| author_facet | Barrows, M. Killick, R. Day, C. Saunders, R. Baiker, Kerstin Ressel, L. Denk, D. |
| author_sort | Barrows, M. |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Five juvenile pied imperial pigeons (Ducula bicolor) presented with neurological signs including torticollis, ataxia and poor flying ability. All were humanely destroyed and submitted for post-mortem examination. Microscopically, the most significant findings were in the brain and spinal cord. Spheroid formation was evident within the medulla, pons, diencephalon, cortical grey and subcortical white matter, spinal cord white and grey matter and the granular and molecular cell layers of the cerebellum. There was no evidence of associated inflammation. Immunohistochemistry revealed positive labelling within the spheroids for S100 axons and phosphorylated neurofilaments including SMI31, neurofilament cocktail and microtubule-associated protein 2. Transmission electron microscopy confirmed the light microscopical findings of frequent axonal spheroids. These results are consistent with neuroaxonal dystrophy, which has not been described previously in pigeons. This highlights the importance of considering neuroaxonal dystrophy in juvenile birds with neurological signs. A genetic basis is suspected in this group. |
| first_indexed | 2025-11-14T20:19:32Z |
| format | Article |
| id | nottingham-51126 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:19:32Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-511262020-05-04T18:47:18Z https://eprints.nottingham.ac.uk/51126/ Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) Barrows, M. Killick, R. Day, C. Saunders, R. Baiker, Kerstin Ressel, L. Denk, D. Five juvenile pied imperial pigeons (Ducula bicolor) presented with neurological signs including torticollis, ataxia and poor flying ability. All were humanely destroyed and submitted for post-mortem examination. Microscopically, the most significant findings were in the brain and spinal cord. Spheroid formation was evident within the medulla, pons, diencephalon, cortical grey and subcortical white matter, spinal cord white and grey matter and the granular and molecular cell layers of the cerebellum. There was no evidence of associated inflammation. Immunohistochemistry revealed positive labelling within the spheroids for S100 axons and phosphorylated neurofilaments including SMI31, neurofilament cocktail and microtubule-associated protein 2. Transmission electron microscopy confirmed the light microscopical findings of frequent axonal spheroids. These results are consistent with neuroaxonal dystrophy, which has not been described previously in pigeons. This highlights the importance of considering neuroaxonal dystrophy in juvenile birds with neurological signs. A genetic basis is suspected in this group. Elsevier 2017-05-30 Article PeerReviewed Barrows, M., Killick, R., Day, C., Saunders, R., Baiker, Kerstin, Ressel, L. and Denk, D. (2017) Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor). Journal of Comparative Pathology, 156 (4). pp. 451-457. ISSN 1532-3129 https://www.sciencedirect.com/science/article/pii/S0021997516304996?via%3Dihub doi:10.1016/j.jcpa.2017.02.006 doi:10.1016/j.jcpa.2017.02.006 |
| spellingShingle | Barrows, M. Killick, R. Day, C. Saunders, R. Baiker, Kerstin Ressel, L. Denk, D. Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title | Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title_full | Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title_fullStr | Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title_full_unstemmed | Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title_short | Neuroaxonal dystrophy in a flock of pied imperial pigeons (Ducula bicolor) |
| title_sort | neuroaxonal dystrophy in a flock of pied imperial pigeons (ducula bicolor) |
| url | https://eprints.nottingham.ac.uk/51126/ https://eprints.nottingham.ac.uk/51126/ https://eprints.nottingham.ac.uk/51126/ |