Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma of the breast is a rare tumor characterized by epithelial-myoepithelial differentiation, of which a subset will progress to invasive or metastatic cancer. We sought to define the genomic landscape of adenomyoepitheliomas. Massively parallel sequencing revealed highly recurrent so...

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Bibliographic Details
Main Authors: Geyer, Felipe C., Li, Anqi, Papanastasiou, Anastasios D., Smith, Alison, Selenica, Pier, Burke, Kathleen A., Edelweiss, Marcia, Wen, Huei-Chi, Piscuoglio, Salvatore, Schultheis, Anne M., Martelotto, Luciano G., Pareja, Fresia, Brandes, Alissa, Lozada, John, Macedo, Gabriel S., de Filippo, Maria R., Jungbluth, Achim A., Foschini, Maria Pia, Wen, Hannah Y., Brogi, Edi, Palazzo, Juan, Rubin, Brian P., Ng, Charlotte K.Y., Norton, Larry, Rakha, Emad A., Varga, Zsuzsanna, Ellis, Ian O., Chandarlapaty, Sarat, Weigelt, Britta, Reis-Filho, Jorge S.
Format: Article
Published: Nature Publishing Group 2018
Subjects:
epithelial-myoepithelial carcinoma
breast cancer
copy number variation
single nucleotide variant
RNA-sequencing
whole-exome sequencing
Online Access:https://eprints.nottingham.ac.uk/51065/

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