The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response

The inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response

Background Idiopathic pulmonary fibrosis (IPF) is 22 a chronic and progressive fibrotic lung disease for which there is no cure. Current therapeutics are only able to slow disease progression, therefore there is a need to explore alternative, novel treatment options. There is increasing evidence tha...

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Bibliographic Details
Main Authors: Roberts, Maxine J., Broome, Rebecca E., Kent, Toby C., Charlton, Steven J., Rosethorne, Elizabeth M.
Format: Article
Language:English
Published: BioMed Central 2018
Subjects:
cAMP; Idiopathic pulmonary fibrosis; human lung fibroblasts; G protein-coupled receptors; drug discovery
Online Access:https://eprints.nottingham.ac.uk/51019/

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