Measuring macroscopic brain connections in vivo
Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can...
| Main Authors: | , , , , |
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| Format: | Article |
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Nature Publishing Group
2015
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| Online Access: | https://eprints.nottingham.ac.uk/50943/ |
| _version_ | 1848798374064553984 |
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| author | Jbabdi, Saad Sotiropoulos, Stamatios N. Haber, Suzanne N. Van Essen, David C. Behrens, Timothy E. |
| author_facet | Jbabdi, Saad Sotiropoulos, Stamatios N. Haber, Suzanne N. Van Essen, David C. Behrens, Timothy E. |
| author_sort | Jbabdi, Saad |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means. |
| first_indexed | 2025-11-14T20:18:45Z |
| format | Article |
| id | nottingham-50943 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:18:45Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-509432020-05-04T17:18:44Z https://eprints.nottingham.ac.uk/50943/ Measuring macroscopic brain connections in vivo Jbabdi, Saad Sotiropoulos, Stamatios N. Haber, Suzanne N. Van Essen, David C. Behrens, Timothy E. Decades of detailed anatomical tracer studies in non-human animals point to a rich and complex organization of long-range white matter connections in the brain. State-of-the art in vivo imaging techniques are striving to achieve a similar level of detail in humans, but multiple technical factors can limit their sensitivity and fidelity. In this review, we mostly focus on magnetic resonance imaging of the brain. We highlight some of the key challenges in analyzing and interpreting in vivo connectomics data, particularly in relation to what is known from classical neuroanatomy in laboratory animals. We further illustrate that, despite the challenges, in vivo imaging methods can be very powerful and provide information on connections that is not available by any other means. Nature Publishing Group 2015-10-27 Article PeerReviewed Jbabdi, Saad, Sotiropoulos, Stamatios N., Haber, Suzanne N., Van Essen, David C. and Behrens, Timothy E. (2015) Measuring macroscopic brain connections in vivo. Nature Neuroscience, 18 (11). pp. 1546-1555. ISSN 1546-1726 https://www.nature.com/articles/nn.4134 doi:10.1038/nn.4134 doi:10.1038/nn.4134 |
| spellingShingle | Jbabdi, Saad Sotiropoulos, Stamatios N. Haber, Suzanne N. Van Essen, David C. Behrens, Timothy E. Measuring macroscopic brain connections in vivo |
| title | Measuring macroscopic brain connections in vivo |
| title_full | Measuring macroscopic brain connections in vivo |
| title_fullStr | Measuring macroscopic brain connections in vivo |
| title_full_unstemmed | Measuring macroscopic brain connections in vivo |
| title_short | Measuring macroscopic brain connections in vivo |
| title_sort | measuring macroscopic brain connections in vivo |
| url | https://eprints.nottingham.ac.uk/50943/ https://eprints.nottingham.ac.uk/50943/ https://eprints.nottingham.ac.uk/50943/ |