Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability

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Multiple linear regression modelling to predict the stability of polymer-drug solid dispersions: comparison of the effects of polymers and manufacturing methods on solid dispersion stability

Solid dispersions can be a successful way to enhance the bioavailability of poorly soluble drugs. Here 60 solid dispersion formulations were produced using ten chemically diverse, neutral, poorly soluble drugs, three commonly used polymers, and two manufacturing techniques, spray drying and melt ext...

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Bibliographic Details
Main Authors:	Fridgeirsdottir, Gudrun, Harris, Robert, Dryden, Ian L., Fischer, Peter M., Roberts, Clive J.
Format:	Article
Published:	American Chemical Society 2018
Subjects:	solid dispersion stability multiple linear regression model hot melt extrusion spray-drying amorphous
Online Access:	https://eprints.nottingham.ac.uk/50924/

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