Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

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Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B

The integrated stress response (ISR) is a conserved translational and transcriptional program affecting metabolism, memory, and immunity. The ISR is mediated by stress-induced phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) that attenuates the guanine nucleotide exchange facto...

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Bibliographic Details
Main Authors:	Zyryanova, Alisa F., Weis, Félix, Faille, Alexandre, Abo Alard, Akeel, Crespillo-Casado, Ana, Sekine, Yusuke, Harding, Heather P., Allen, Felicity, Parts, Leopold, Fromont, Christoph, Fischer, Peter M., Warren, Alan J., Ron, David
Format:	Article
Language:	English
Published:	American Association for the Advancement of Science 2018
Online Access:	https://eprints.nottingham.ac.uk/50909/

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