Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study
Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout. Methods: One hundred gout patients initiated on up-titrated ULT between March and July 2010 were sent a questionnaire that elicited informa...
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Oxford University Press
2016
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| Online Access: | https://eprints.nottingham.ac.uk/50858/ |
| _version_ | 1848798357438332928 |
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| author | Abhishek, Abhishek Jenkins, Wendy La-Crette, Jonathan Fernandes, Gwen Sascha Doherty, Michael |
| author_facet | Abhishek, Abhishek Jenkins, Wendy La-Crette, Jonathan Fernandes, Gwen Sascha Doherty, Michael |
| author_sort | Abhishek, Abhishek |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout.
Methods: One hundred gout patients initiated on up-titrated ULT between March and July 2010 were sent a questionnaire that elicited information on current ULT, reasons for discontinuation of ULT if applicable, medication adherence and generic and disease-specific quality-of-life measures in 2015. They were invited for one visit at which height and weight were measured and blood was collected for serum uric acid measurement.
Results: Seventy-five patients, mean age 68.13 years ( s . d . 10.07) and disease duration 19.44 years ( s . d . 13), returned completed questionnaires. The 5-year persistence on ULT was 90.7% (95% CI 81.4, 91.6) and 85.3% of responders self-reported taking ULT ⩾6 days/week. Of the 65 patients who attended the study visit, the mean serum uric acid was 292.8 μmol/l ( s . d . 97.2).
Conclusion: An initial treatment that includes individualized patient education and involvement in treatment decisions results in excellent adherence and persistence on ULT >4 years after the responsibility of treatment is taken over by the patient's general practitioner, suggesting that this model of gout management should be widely adopted. |
| first_indexed | 2025-11-14T20:18:29Z |
| format | Article |
| id | nottingham-50858 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:18:29Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-508582020-05-04T18:26:10Z https://eprints.nottingham.ac.uk/50858/ Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study Abhishek, Abhishek Jenkins, Wendy La-Crette, Jonathan Fernandes, Gwen Sascha Doherty, Michael Objectives: To evaluate the persistence and adherence on urate-lowering treatment (ULT) in primary care 5 years after an initial nurse-led treatment of gout. Methods: One hundred gout patients initiated on up-titrated ULT between March and July 2010 were sent a questionnaire that elicited information on current ULT, reasons for discontinuation of ULT if applicable, medication adherence and generic and disease-specific quality-of-life measures in 2015. They were invited for one visit at which height and weight were measured and blood was collected for serum uric acid measurement. Results: Seventy-five patients, mean age 68.13 years ( s . d . 10.07) and disease duration 19.44 years ( s . d . 13), returned completed questionnaires. The 5-year persistence on ULT was 90.7% (95% CI 81.4, 91.6) and 85.3% of responders self-reported taking ULT ⩾6 days/week. Of the 65 patients who attended the study visit, the mean serum uric acid was 292.8 μmol/l ( s . d . 97.2). Conclusion: An initial treatment that includes individualized patient education and involvement in treatment decisions results in excellent adherence and persistence on ULT >4 years after the responsibility of treatment is taken over by the patient's general practitioner, suggesting that this model of gout management should be widely adopted. Oxford University Press 2016-12-12 Article PeerReviewed Abhishek, Abhishek, Jenkins, Wendy, La-Crette, Jonathan, Fernandes, Gwen Sascha and Doherty, Michael (2016) Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study. Rheumatology, 56 (4). pp. 529-533. ISSN 1462-0332 gout urate lowering treatment persistence adherence https://academic.oup.com/rheumatology/article/56/4/529/2671019 doi:10.1093/rheumatology/kew395 doi:10.1093/rheumatology/kew395 |
| spellingShingle | gout urate lowering treatment persistence adherence Abhishek, Abhishek Jenkins, Wendy La-Crette, Jonathan Fernandes, Gwen Sascha Doherty, Michael Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title | Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title_full | Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title_fullStr | Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title_full_unstemmed | Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title_short | Long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| title_sort | long-term persistence and adherence on urate-lowering treatment can be maintained in primary care-5-year follow-up of a proof-of-concept study |
| topic | gout urate lowering treatment persistence adherence |
| url | https://eprints.nottingham.ac.uk/50858/ https://eprints.nottingham.ac.uk/50858/ https://eprints.nottingham.ac.uk/50858/ |