Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study
AIM: To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. METHODS: A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit...
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| Format: | Article |
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BMJ
2017
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| Online Access: | https://eprints.nottingham.ac.uk/50837/ |
| _version_ | 1848798352665214976 |
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| author | Matthews, Yim-Yee Dean, Fiona Lim, Ming J. Mclachlan, Karen Rigby, Alan S. Solanki, Guirish A. White, Catherine P. Whitehouse, William P. Kennedy, Colin R. |
| author_facet | Matthews, Yim-Yee Dean, Fiona Lim, Ming J. Mclachlan, Karen Rigby, Alan S. Solanki, Guirish A. White, Catherine P. Whitehouse, William P. Kennedy, Colin R. |
| author_sort | Matthews, Yim-Yee |
| building | Nottingham Research Data Repository |
| collection | Online Access |
| description | AIM:
To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years.
METHODS:
A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using classical diagnostic criteria and categorised according to 2013 revised diagnostic criteria. We derived national age, sex and weight-specific annual incidence rates and assessed effects of sex and weight categories.
RESULTS:
We identified 185 PTCS cases of which 166 also fulfilled revised diagnostic criteria. The national annual incidence (95% CI) of PTCS in children aged 1-16 years was 0.71 (0.57 to 0.87) per 100 000 population increasing with age and weight to 4.18 and 10.7 per 100 000 in obese boys and girls aged 12-15 years, respectively. Incidence rates under 7 years were similar in both sexes. From 7 years onwards, the incidence in girls was double that in boys, but only in overweight (including obese) children. In children aged 12-15 years, an estimated 82% of the incidence of PTCS was attributable to obesity. Two subgroups of PTCS were apparent: 168 (91%) cases aged from 7 years frequently presented on medication and with headache and were predominantly female and obese. The remaining 17 (9%) cases under 7 years often lacked these risk factors and commonly presented with paralytic squint.
CONCLUSIONS:
This uniquely large population-based study of childhood PTCS will inform the design of future intervention studies. It suggests that weight reduction is central to the prevention of PTCS.
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. |
| first_indexed | 2025-11-14T20:18:25Z |
| format | Article |
| id | nottingham-50837 |
| institution | University of Nottingham Malaysia Campus |
| institution_category | Local University |
| last_indexed | 2025-11-14T20:18:25Z |
| publishDate | 2017 |
| publisher | BMJ |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | nottingham-508372020-05-04T18:39:22Z https://eprints.nottingham.ac.uk/50837/ Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study Matthews, Yim-Yee Dean, Fiona Lim, Ming J. Mclachlan, Karen Rigby, Alan S. Solanki, Guirish A. White, Catherine P. Whitehouse, William P. Kennedy, Colin R. AIM: To investigate the epidemiology, clinical profile and risk factors of pseudotumor cerebri syndrome (PTCS) in children aged 1-16 years. METHODS: A national prospective population-based cohort study over 25 months. Newly diagnosed PTCS cases notified via British Paediatric Surveillance Unit were ascertained using classical diagnostic criteria and categorised according to 2013 revised diagnostic criteria. We derived national age, sex and weight-specific annual incidence rates and assessed effects of sex and weight categories. RESULTS: We identified 185 PTCS cases of which 166 also fulfilled revised diagnostic criteria. The national annual incidence (95% CI) of PTCS in children aged 1-16 years was 0.71 (0.57 to 0.87) per 100 000 population increasing with age and weight to 4.18 and 10.7 per 100 000 in obese boys and girls aged 12-15 years, respectively. Incidence rates under 7 years were similar in both sexes. From 7 years onwards, the incidence in girls was double that in boys, but only in overweight (including obese) children. In children aged 12-15 years, an estimated 82% of the incidence of PTCS was attributable to obesity. Two subgroups of PTCS were apparent: 168 (91%) cases aged from 7 years frequently presented on medication and with headache and were predominantly female and obese. The remaining 17 (9%) cases under 7 years often lacked these risk factors and commonly presented with paralytic squint. CONCLUSIONS: This uniquely large population-based study of childhood PTCS will inform the design of future intervention studies. It suggests that weight reduction is central to the prevention of PTCS. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/. BMJ 2017-03-29 Article PeerReviewed Matthews, Yim-Yee, Dean, Fiona, Lim, Ming J., Mclachlan, Karen, Rigby, Alan S., Solanki, Guirish A., White, Catherine P., Whitehouse, William P. and Kennedy, Colin R. (2017) Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study. Archives of Disease in Childhood, 102 (8). pp. 715-721. ISSN 1468-2044 BPSU; Epidemiology; Obesity; Idiopathic intracranial hypertension; Pseudotumor cerebri http://adc.bmj.com/content/102/8/715 doi:10.1136/archdischild-2016-312238 doi:10.1136/archdischild-2016-312238 |
| spellingShingle | BPSU; Epidemiology; Obesity; Idiopathic intracranial hypertension; Pseudotumor cerebri Matthews, Yim-Yee Dean, Fiona Lim, Ming J. Mclachlan, Karen Rigby, Alan S. Solanki, Guirish A. White, Catherine P. Whitehouse, William P. Kennedy, Colin R. Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based cohort study |
| title | Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| title_full | Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| title_fullStr | Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| title_full_unstemmed | Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| title_short | Pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| title_sort | pseudotumor cerebri syndrome in childhood: incidence, clinical profile and risk factors in a national prospective population-based
cohort study |
| topic | BPSU; Epidemiology; Obesity; Idiopathic intracranial hypertension; Pseudotumor cerebri |
| url | https://eprints.nottingham.ac.uk/50837/ https://eprints.nottingham.ac.uk/50837/ https://eprints.nottingham.ac.uk/50837/ |