Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737

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Quantitative assessment of the sensitivity of dormant AML cells to the BAD mimetics ABT-199 and ABT-737

Cells from patients with acute myeloid leukaemia (AML) that remain dormant and protected by stromal cells may escape effects of chemotherapy. We modelled dormancy in vitro and investigated the ability of Bcl-2 inhibitors ABT-199 and ABT-737 to overcome chemoprotection of dormant cells. CD34-enriched...

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Bibliographic Details
Main Authors:	Yu, Ning, Seedhouse, Claire, Russell, Nigel, Pallis, Monica
Format:	Article
Published:	Taylor & Francis 2018
Subjects:	AML; ABT-199; ABT-737; dormancy
Online Access:	https://eprints.nottingham.ac.uk/50748/

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