Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes

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Micro-pharmacokinetics: quantifying local drug concentration at live cell membranes

Fundamental equations for determining pharmacological parameters, such as the binding afnity of a ligand for its target receptor, assume a homogeneous distribution of ligand, with concentrations in the immediate vicinity of the receptor being the same as those in the bulk aqueous phase. It is, howev...

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Bibliographic Details
Main Authors:	Gherbi, Karolina, Briddon, Stephen J., Charlton, Steven J.
Format:	Article
Published:	Nature Publishing Group 2018
Online Access:	https://eprints.nottingham.ac.uk/50608/

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