Biased agonism in drug discovery: is it too soon to choose a path?

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Biased agonism in drug discovery: is it too soon to choose a path?

A single receptor can activate multiple signaling pathways that have distinct or even opposite effects on cell function. Biased agonists stabilize receptor conformations preferentially stimulating one of these pathways, and therefore allow a more targeted modulation of cell function and treatment of...

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Bibliographic Details
Main Authors:	Michel, Martin C., Charlton, Steven J.
Format:	Article
Language:	English
Published:	American Society for Pharmacology and Experimental Therapeutics 2018
Online Access:	https://eprints.nottingham.ac.uk/50607/

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